5-溴-2-二甲基氨基吡啶合成路线 （共 24 条）
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=100°C; 24 h;
参考文献
Qin, Lijin; Cui, Hongmeng; Zou, Dapeng; Li, Jingya; Wu, Yangjie; Zhu, Zhiwu; Wu, Yusheng
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4445 - 4448
反应条件
1: 65 percent / piperidine; CuI / Pd(PPh3)2Cl2 / 20 h / 100 °C
2: 96 percent / K2CO3 / methanol
View Scheme
参考文献
Cai, Liangzhen; Yang, Dujuan; Sun, Zhonghua; Tao, Xiaochun; Cai, Lisheng; Pike, Victor W.
Chinese Journal of Chemistry, 2011 , vol. 29, # 5 p. 1059 - 1062
反应条件
n-butyllithium; sulfur in tetrahydrofuran; hexane
T=-78°C; 0.433333 h;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: WO2004/33418 A2, 2004 ;
Location in patent: Page 34 ;
WO 2004/033418 A2
反应条件
potassium phosphate; (C5H5FeC5H3C(CH3)NC6H4CH3)PdCl(tricyclohexylphosphine); potassium acetate in 1,4-dioxane; water
T=100°C; Suzuki coupling; 15 h; Inert atmosphere;
参考文献
Wang, Lianhui; Cui, Xiuling; Li, Jingya; Wu, Yusheng; Zhu, Zhiwu; Wu, Yangjie
European Journal of Organic Chemistry, 2012 , # 3 p. 595 - 603
