2-甲基-6-三氟甲基吡啶-3-羧酸合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol; water; ethyl acetate
参考文献
Ruegg, Willy T.
Patent: US2004/106519 A1, 2004 ;
反应条件
sodium hydroxide in methanol
参考文献
Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906
反应条件
acetyl chloride 6 h; Reflux;
参考文献
WO2012/61926 A1, ;
Page/Page column 39 ;
WO 2012/061926 A1
反应条件
thionyl chloride in toluene Heating;
参考文献
Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906
参考文献
Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang
Patent: US2003/195201 A1, 2003 ;
US 20030195201 A1
参考文献
Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang
Patent: US2003/195201 A1, 2003 ;
US 20030195201 A1
