1: 4-methoxy-aniline With hydrogenchloride; sulfuric acid; sodium nitrite in water T=5 - 65°C; 2: 2-amino-4-phenyl-1,3-thiazole With sodium carbonate in water T=0 - 5°C; pH=5 - 6; 2 h;

in ethanol Heating;

1: I2 2: 1.) NaNO2, 3N HCl; 2.) NaOAc / 1.) water, 0 deg C; 2.) water, ethanol, 2 h View Scheme

in benzene Heating;