(2R)-3-溴-2-羟基-2-甲基丙酸合成路线 （共 7 条）
反应条件
hydrogen bromide in water 1 h; Heating / reflux;
参考文献
GTX, INC.
Patent: WO2007/27582 A2, 2007 ;
Location in patent: Page/Page column 61 ;
反应条件
hydrogenchloride; water 4 h; Reflux;
参考文献
CONSIGLIO NAZIONALE DELLE RICERCHE; ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (I.R.S.T.) S.R.L.; VARCHI, Greta; TESEI, Anna; GUERRINI, Andrea; BRIGLIADORI, Giovanni
Patent: WO2010/116342 A2, 2010 ;
Location in patent: Page/Page column 42 ;
反应条件
1: (2R)-3-Bromo-2-hydroxy-2-methylpropanoic Acid With thionyl chloride in isobutyramide T=-10°C; Inert atmosphere; 2: 4-amino-2-(trifluoromethyl)benzonitrile in isobutyramide T=20°C;
参考文献
CONSIGLIO NAZIONALE DELLE RICERCHE; ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (I.R.S.T.) S.R.L.; VARCHI, Greta; TESEI, Anna; GUERRINI, Andrea; BRIGLIADORI, Giovanni
Patent: WO2010/116342 A2, 2010 ;
Location in patent: Page/Page column 42-43 ;
反应条件
thionyl chloride; triethylamine in tetrahydrofuran; water
参考文献
Dalton, James T.; Eswaraka, Jeetendra
Patent: US2011/172302 A1, 2011 ;
反应条件
thionyl chloride; triethylamine in tetrahydrofuran; water
参考文献
Dalton, James T.; Eswaraka, Jeetendra
Patent: US2011/172302 A1, 2011 ;
反应条件
thionyl chloride in N,N-dimethyl acetamide T=20°C;
参考文献
Steiner, Mitchell S.; Veverka, Karen A.; Miller, Duane D.
Patent: US2006/258628 A1, 2006 ;
Location in patent: Page/Page column 23 ;
反应条件
thionyl chloride in dimethylammonium 2,4-dichlorophenoxyacetate
参考文献
Dalton, James T.; Miller, Duane D.; Yin, Donghua; He, Yali
Patent: US2004/260108 A1, 2004 ;
