2-膦酰-4-戊炔酸三乙酯合成路线 （共 7 条）
反应条件
sodium hydride in tetrahydrofuran 1.) room temp., 6 h, 2.) reflux, 3 h;
参考文献
Ravikumar, V.T.; Swaminathan, S.; Rajagopalan, K.
Tetrahedron Letters, 1984 , vol. 25, # 52 p. 6045 - 6046
反应条件
potassium carbonate; sodium iodide T=60°C; 120 h; Yields of byproduct given;
参考文献
Kirschleger, Bernard; Queignec, Rene
Synthesis, 1986 , # 11 p. 926 - 928
反应条件
in tetrahydrofuran; anhydrous xylene T=-15 - 20°C;
参考文献
Artyushin, Oleg I.; Osipov, Sergey N.; Roeschenthaler, Gerd-Volker; Odinets, Irina L.
Synthesis, 2009 , # 21 p. 3579 - 3588
反应条件
1: 60 percent / saturated agueous potassium carbonate
2: 62 percent / NaH / dimethylsulfoxide / 1.) 8 h, 25 deg C, 2.) 4 h, 80 deg C
View Scheme
参考文献
Ravikumar, V.T.; Swaminathan, S.; Rajagopalan, K.
Tetrahedron Letters, 1984 , vol. 25, # 52 p. 6045 - 6046
反应条件
1: 50 percent / K2CO3 / H2O / 1 h / 50 - 55 °C
2: 45 percent / Hg(OAc)2 / pyridine; ethanol / 4 h / Heating
3: 76 percent / NaBH4 / ethanol / Ambient temperature
4: 1) NaOH, 2) dil. HCl / 1) H2O, r.t., 4 h, 2) H2O, 3 h
View Scheme
参考文献
Ravikumar, V. T.; Swaminathan, S.; Rajagopalan, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 292 - 293
参考文献
Ravikumar, V.T.; Swaminathan, S.; Rajagopalan, K.
Tetrahedron Letters, 1984 , vol. 25, # 52 p. 6045 - 6046
反应条件
formaldehyd; potassium carbonate
T=50 - 55°C; 1 h;
参考文献
Ravikumar, V. T.; Thangaraj, K.; Swaminathan, S.; Rajagopalan, K.
Synthesis, 1985 , # 10 p. 985 - 986
