N-(4-氨基苯基)-N-甲基-2-(4-甲基哌嗪-1-基)乙酰胺合成路线 （共 8 条）
反应条件
1: in toluene T=40 - 55°C; 2.5 h; 2: With hydrogen; palladium on activated charcoal in isopropyl alcohol; toluene T=20°C; P=750.075 Torr;
参考文献
WO2012/68441 A2, ;
Page/Page column 13; 14 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=2585.81 Torr; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 14 p. 4466 - 4480
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 5 - 20 °C 2.1: toluene / 2.5 h / 40 - 55 °C 2.2: 20 °C / 750.08 Torr View Scheme
反应条件
1: in DMF (N,N-dimethyl-formamide) T=80°C; 1 h; 2: With piperidine in DMF (N,N-dimethyl-formamide) T=20°C; 2 h;
参考文献
WO2004/13099 A1, ;
Page 13 ;
反应条件
piperidine in DMF (N,N-dimethyl-formamide) T=20 - 80°C; 3 h;
参考文献
EP1473043 A1, ;
Page 6 ;
EP 1473043 A1
反应条件
in methanol 8 h; Reflux;
参考文献
WO2012/68441 A2, ;
Page/Page column 11 ;
反应条件
in methanol T=10°C; 9.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2009/71524 A2, ;
Page/Page column 22-23; 13 ;
反应条件
1: in N,N-dimethyl-formamide T=80°C; 1 h; 2: With piperidine in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 14 p. 4466 - 4480
