4-(2-吗啉-4-乙基)-苯胺合成路线 （共 8 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate P=750.075 Torr; 72 h;
参考文献
Angewandte Chemie, International Edition, , vol. 51, # 42 p. 10500 - 10504,5
Angewandte Chemie, , vol. 124, # 42 p. 10652 - 10656,5
Angewandte Chemie - International Edition, , vol. 51, # 42 p. 10500 - 10504
Angew. Chem., , vol. 124, # 42 p. 10652 - 10656,5
反应条件
1: N,N-dimethyl-formamide / 16 h / 80 °C 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 72 h / 750.08 Torr View Scheme
参考文献
Angewandte Chemie, International Edition, , vol. 51, # 42 p. 10500 - 10504,5
Angewandte Chemie, , vol. 124, # 42 p. 10652 - 10656,5
Angewandte Chemie - International Edition, , vol. 51, # 42 p. 10500 - 10504
Angew. Chem., , vol. 124, # 42 p. 10652 - 10656,5
反应条件
1: With anhydrous iron chloride in methanol Heating / reflux; 2: With hydrazine in methanol 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/18941 A2, ;
Page/Page column 64 ;
WO 2007/018941 A2
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 2: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: water / 20 °C 2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 3: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: triphenylphosphine / dichloromethane / 0 °C 2: water / 20 °C 3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / Reflux 4: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 1 p. 285 - 296
反应条件
1: potassium iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 9.5 h / 80 - 100 °C / |Inert atmosphere 2: hydrogenchloride; tin(IV) chloride / water / 2 h / 20 °C / |Reflux View Scheme
