1: 2,4-Dichloropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran 1 h; Cooling with hexane-dry iceInert atmosphere; 2: carbon dioxide in tetrahydrofuran T=-60°C; 0.5 h; Cooling with hexane-dry iceInert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran

1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; benzene T=-78°C; 2 h; 2: With carbon dioxide T=-78 - 20°C; 3: With hydrogenchloride; potassium hydroxide; water more than 3 stages;

1: 2,4-Dichloropyridine With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - 20°C; 0.166667 h; 3: With hydrogenchloride; water pH=4;

1: 2,4-dichloro-3-iodo-pyridine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide T=-78°C;

1.1: 2,2,6,6-tetramethylpiperidine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 76 percent / iodine / tetrahydrofuran 2.1: 79 percent / butyllithium; diisopropylamine / tetrahydrofuran; hexane / 4 h / -75 °C 3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C 3.2: 67 percent / N-chlorosuccinimide / tetrahydrofuran / 1 h / 25 °C 4.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 4.2: 88 percent / -78 °C View Scheme

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C 1.2: 67 percent / N-chlorosuccinimide / tetrahydrofuran / 1 h / 25 °C 2.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 88 percent / -78 °C View Scheme

1.1: 79 percent / butyllithium; diisopropylamine / tetrahydrofuran; hexane / 4 h / -75 °C 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C 2.2: 67 percent / N-chlorosuccinimide / tetrahydrofuran / 1 h / 25 °C 3.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 3.2: 88 percent / -78 °C View Scheme

1: N-methyl-N-nitrosourea With potassium hydroxide in diethyl ether; water 2: 2,4-dichloronicotinic acid in methanol; diethyl ether T=0 - 20°C; 1 h;

1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile

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