(3-溴-5-甲氧基苯基)甲醇合成路线 （共 6 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=20 - 65°C; 5 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITE DE MONTREAL; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; TREMBLAY, Francois Tremblay; MARTEL, Alain; MARINIER, Anne
Patent: WO2013/163241 A1, 2013 ;
Location in patent: Paragraph 00152 ;
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C;
参考文献
Roche Palo Alto LLC
Patent: US2004/186092 A1, 2004 ;
Location in patent: Page/Page column 20-21 ;
US 20040186092 A1
反应条件
sodium tetrahydroborate; ethanol in tetrahydrofuran T=20°C; 3 h; Cooling with ice;
参考文献
ASAHI KASEI PHARMA CORPORATION
Patent: US2010/261701 A1, 2010 ;
Location in patent: Page/Page column 119 ;
反应条件
1: 50 percent / aq. KMnO4; pyridine / 24 h / 75 °C 2: 81 percent / LiAlH4 / diethyl ether / 3 h / 20 °C View Scheme
参考文献
Claudi, Francesco; Di Stefano, Antonio; Napolitani, Fabrizio; Cingolani, Gian Mario; Giorgioni, Gianfabio; Fontenla, Jose A.; Montenegro, Gisela Y.; Rivas, Maria E.; Rosa, Elizabeth; Michelotto, Barbara; Orlando, Giustino; Brunetti, Luigi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 599 - 608
反应条件
pyridinium chlorochromate in dichloromethane Oxidation; 2 h;
参考文献
Claudi, Francesco; Di Stefano, Antonio; Napolitani, Fabrizio; Cingolani, Gian Mario; Giorgioni, Gianfabio; Fontenla, Jose A.; Montenegro, Gisela Y.; Rivas, Maria E.; Rosa, Elizabeth; Michelotto, Barbara; Orlando, Giustino; Brunetti, Luigi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 599 - 608
反应条件
phosphorus tribromide in dichloromethane
T=0 - 20°C; 0.166667 h;
参考文献
ASAHI KASEI PHARMA CORPORATION
Patent: US2010/261701 A1, 2010 ;
Location in patent: Page/Page column 119 ;
