(S)-1-Boc-哌啶-2-羧酸合成路线 （共 49 条）
反应条件
hydrogen; RuCl2; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in methanol T=45°C; Reduction; P=51716.2 Torr; 11 h;
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
反应条件
sodium carbonate in 1,4-dioxane; water; ethyl acetate
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5484926 A1, 1996 ;
反应条件
TEA in methanol a) 50 deg C, 5 min, b) RT, 1 h;
参考文献
Thai, Dung L.; Sapko, Michael T.; Reiter, Clara T.; Bierer, Donald E.; Perel, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 591 - 601
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Ginesta, Xavier; Pericas, Miquel A; Riera, Antoni
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 779 - 782
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Moldvai, Istvan; Doernyei, Gabor; Temesvari-Major, Eszter; Szantay, Csaba
Organic Preparations and Procedures International, 2007 , vol. 39, # 5 p. 503 - 508
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Pfizer Inc.
Patent: US6610707 B1, 2003 ;
反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; cyclohexane T=-78°C; 3 h; Inert atmosphere; 2: With C12H24N2O(2-)*2Li(1+) in diethyl ether; cyclohexane T=-45°C; 3 h; Inert atmosphere; 3: carbon dioxide in diethyl ether; cyclohexane T=-78°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Beng, Timothy K.; Gawley, Robert E.
Journal of the American Chemical Society, 2010 , vol. 132, # 35 p. 12216 - 12217
反应条件
triethylamine in water; acetone
参考文献
Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31
反应条件
potassium permanganate; sodium periodate; sodium carbonate in 1,4-dioxane; water
参考文献
Ginesta, Xavier; Pericas, Miquel A; Riera, Antoni
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 779 - 782
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
