2-苄基-3-叔丁氧羰基氨基丙酸合成路线 （共 27 条）
反应条件
1: (2S)-N-{(2R)-2-[(dibenzylamino)methyl]-3-phenylpropanoyl}camphorsultam With palladium on activated charcoal in tetrahydrofuran; methanol T=20°C; 2: With lithium hydroxide in tetrahydrofuran; water T=20°C; 3: di-tert-butyl dicarbonate With potassium carbonate in 1,4-dioxane 5 h; Further stages.;
参考文献
Moumne, Roba; Denise, Bernard; Guitot, Karine; Rudler, Henri; Lavielle, Solange; Karoyan, Philippe
European Journal of Organic Chemistry, 2007 , # 12 p. 1912 - 1920
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 6 h;
参考文献
Tessier, Arnaud; Lahmar, Nour; Pytkowicz, Julien; Brigaud, Thierry
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3970 - 3973
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=-5 - 0°C; Hydrolysis;
参考文献
Sibi, Mukund P.; Deshpande, Prasad K.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1461 - 1466
反应条件
bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; (S)-3,3'-dimethylmonophos; tris (α-naphthyl)phosphine; hydrogen in isopropyl alcohol T=30°C; P=18751.9 Torr; 20 h; Inert atmosphere; Catalytic behavior; Reagent/catalystSolventPressureTemperature; enantioselective reaction;
参考文献
Luehr, Susan; Holz, Jens; Zayas, Odalys; Wendisch, Volkmar; Boerner, Armin
Tetrahedron Asymmetry, 2012 , vol. 23, # 17 p. 1301 - 1319
反应条件
lithium hydroxide in tetrahydrofuran 1.5 h; Ambient temperature;
参考文献
Zelle
Synthesis, 1991 , # 11 p. 1023 - 1026
反应条件
1: (R)-2-Aminomethyl-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-phenyl-propan-1-one; hydrochloride With lithium hydroxide; tetrabutylammomium bromide; lithium bromide in acetonitrile saponification; 3 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in ethanol T=20°C; Condensation; Further stages.;
参考文献
Ponsinet, Rachel; Chassaing, Gerard; Vaissermann, Jacqueline; Lavielle, Solange
European Journal of Organic Chemistry, 2000 , # 1 p. 83 - 90
反应条件
jones reagent in acetone T=20°C; 1 h;
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
1.1: 75 percent / HCl; H2O / tetrahydrofuran / 20 °C 2.1: LiOH*H2O; nBu4NBr; LiBr / acetonitrile / 3 h 2.2: NaHCO3 / ethanol / 20 °C View Scheme
参考文献
Ponsinet, Rachel; Chassaing, Gerard; Vaissermann, Jacqueline; Lavielle, Solange
European Journal of Organic Chemistry, 2000 , # 1 p. 83 - 90
反应条件
1.1: 94 percent / lipase PS-30 (Amano) / tetrahydrofuran / 2 h / 20 °C 2.1: HN3; diethyl azodicarboxylate; PPh3 / benzene; tetrahydrofuran / -35 - 20 °C 2.2: H2 / Pd-C / ethyl acetate / 20 °C 3.1: 62 percent / K2CO3; H2O / methanol / 2 h / 20 °C 4.1: Jones reagent / acetone / 1 h / 20 °C View Scheme
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
1.1: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C 2.1: 94 percent / lipase PS-30 (Amano) / tetrahydrofuran / 2 h / 20 °C 3.1: HN3; diethyl azodicarboxylate; PPh3 / benzene; tetrahydrofuran / -35 - 20 °C 3.2: H2 / Pd-C / ethyl acetate / 20 °C 4.1: 62 percent / K2CO3; H2O / methanol / 2 h / 20 °C 5.1: Jones reagent / acetone / 1 h / 20 °C View Scheme
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
