2-苄基-3-叔丁氧羰基氨基丙酸合成路线 （共 27 条）
反应条件
1.1: HN3; diethyl azodicarboxylate; PPh3 / benzene; tetrahydrofuran / -35 - 20 °C 1.2: H2 / Pd-C / ethyl acetate / 20 °C 2.1: 62 percent / K2CO3; H2O / methanol / 2 h / 20 °C 3.1: Jones reagent / acetone / 1 h / 20 °C View Scheme
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
1.1: 82 percent / NaH / tetrahydrofuran / 2 h / 20 °C 2.1: 95 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C 3.1: 94 percent / lipase PS-30 (Amano) / tetrahydrofuran / 2 h / 20 °C 4.1: HN3; diethyl azodicarboxylate; PPh3 / benzene; tetrahydrofuran / -35 - 20 °C 4.2: H2 / Pd-C / ethyl acetate / 20 °C 5.1: 62 percent / K2CO3; H2O / methanol / 2 h / 20 °C 6.1: Jones reagent / acetone / 1 h / 20 °C View Scheme
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
1: 87 percent / 4-dimethylaminopyridine, Et3N / CH2Cl2 / 4 h / Ambient temperature 2: 89 percent / 1N LiOH / tetrahydrofuran / 1.5 h / Ambient temperature View Scheme
参考文献
Zelle
Synthesis, 1991 , # 11 p. 1023 - 1026
反应条件
1: sodium carbonate; C29H28F6N4OS / m-xylene; water / 24 h / 20 °C 2: ammonium formate; palladium 10 on activated carbon / #tert!-butyl alcohol / 2 h / 60 °C View Scheme
参考文献
Tite, Tony; Sabbah, Mohamad; Levacher, Vincent; Briere, Jean-Francois
Chemical Communications, 2013 , vol. 49, # 98 p. 11569 - 11571
反应条件
1: 1,2-diamino-benzene; L-proline / ethanol / 24 h / 20 °C 2: sodium carbonate; C29H28F6N4OS / m-xylene; water / 24 h / 20 °C 3: ammonium formate; palladium 10 on activated carbon / #tert!-butyl alcohol / 2 h / 60 °C View Scheme
参考文献
Tite, Tony; Sabbah, Mohamad; Levacher, Vincent; Briere, Jean-Francois
Chemical Communications, 2013 , vol. 49, # 98 p. 11569 - 11571
反应条件
1: 1,2-diamino-benzene; L-proline / ethanol / 24 h / 20 °C 2: sodium carbonate; C29H28F6N4OS / m-xylene; water / 24 h / 20 °C 3: ammonium formate; palladium 10 on activated carbon / #tert!-butyl alcohol / 2 h / 60 °C View Scheme
参考文献
Tite, Tony; Sabbah, Mohamad; Levacher, Vincent; Briere, Jean-Francois
Chemical Communications, 2013 , vol. 49, # 98 p. 11569 - 11571
反应条件
1: HCl / H2O; tetrahydrofuran / 20 °C 2: LiOH; LiBr; tetrabutylammonium bromide / acetonitrile / 20 h / 20 °C 3: LiOH / diethyl ether; H2O / 20 h View Scheme
参考文献
Wozniak; Szymanska; Oldziej; Lankiewicz; Grzonka
Polish Journal of Chemistry, 2006 , vol. 80, # 2 p. 265 - 277
反应条件
1.1: LDA / tetrahydrofuran; hexane; various solvent(s) / 1 h / -78 °C 1.2: 32 percent / tetrahydrofuran; hexane; various solvent(s) / 3 h / -78 °C 2.1: HCl / H2O; tetrahydrofuran / 20 °C 3.1: LiOH; LiBr; tetrabutylammonium bromide / acetonitrile / 20 h / 20 °C 4.1: LiOH / diethyl ether; H2O / 20 h View Scheme
参考文献
Wozniak; Szymanska; Oldziej; Lankiewicz; Grzonka
Polish Journal of Chemistry, 2006 , vol. 80, # 2 p. 265 - 277
反应条件
1: Et3N / acetone / 0.25 h / 0 °C 2: aq. NaN3 / acetone / 15 h / 0 °C 3: toluene / 1 h / Heating 4: toluene / 12 h / Heating 5: 87 percent / H2O2; aq. LiOH / tetrahydrofuran / -5 - 0 °C View Scheme
参考文献
Sibi, Mukund P.; Deshpande, Prasad K.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1461 - 1466
反应条件
1: 93 percent / CF3COOH / CH2Cl2 / 12 h / 20 °C 2: Et3N / acetone / 0.25 h / 0 °C 3: aq. NaN3 / acetone / 15 h / 0 °C 4: toluene / 1 h / Heating 5: toluene / 12 h / Heating 6: 87 percent / H2O2; aq. LiOH / tetrahydrofuran / -5 - 0 °C View Scheme
参考文献
Sibi, Mukund P.; Deshpande, Prasad K.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1461 - 1466
