1: 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2(1H)-thione With sodium hydride in tetrahydrofuran T=-20 - 25°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=25°C; 1 h; Inert atmosphere;

1: 6-(2-thienyl)-4-(trifluoromethyl)pyrimidine-2-(1H)-thione With sodium hydride in tetrahydrofuran T=-20 - 25°C; 0.25 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=25°C; 1 h; Inert atmosphere;

1.1: hydrogenchloride / ethanol; water / 8 h / 95 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran / 0.25 h / -20 - 25 °C / Inert atmosphere 2.2: 1 h / 25 °C / Inert atmosphere View Scheme

(i) aq. K2CO3, (ii) /BRN= 5419949/, CHCl3; Multistep reaction;