(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: 78 percent / dimethylsulfoxide / 72 h / 50 °C 2: 74 percent / NaHCO3; NaI / dimethylformamide / 7 h / 20 °C 3: SOCl2 / CH2Cl2 / 2 h / Heating 4: 380 mg / LiHMDS / tetrahydrofuran / 2 h / -78 - 20 °C View Scheme
参考文献
Couty, Francois; Evano, Gwilherm; Vargas-Sanchez, Monica; Bouzas, Gloria
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 9028 - 9031
反应条件
tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene 1.5 h; Heating;
参考文献
Buckley, Benjamin R.; Neary, Stephen P.; Elsegood, Mark R.J.
Tetrahedron Asymmetry, 2010 , vol. 21, # 16 p. 1959 - 1962
反应条件
sulfuryl dichloride; triethylamine in dichloromethane T=-78°C; 0.25 h;
参考文献
Hawkins, Joel M.; Sharpless, K. Barry
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3861 - 3862
反应条件
di-tert-butyl peroxide; [IndBox]Cu T=80°C; 24 h;
参考文献
US2011/213146 A1, ;
Page/Page column 3; 27 ;
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / Pd/C / tetrahydrofuran / 760 Torr View Scheme
参考文献
Uccello-Barretta; Bernardini; Balzano; Salvadori
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 123 - 129
反应条件
1: sec-phenethyl alcohol With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 16 h; 2: (S)-1-phenyl-ethylamine With sodium tris(acetoxy)borohydride in dichloromethane optical yield given as percent dechemoselective reaction;
参考文献
Guerin, Claire; Bellosta, Veronique; Guillamot, Gerard; Cossy, Janine
Organic Letters, 2011 , vol. 13, # 13 p. 3534 - 3537
反应条件
1: titanium(IV) isopropylate / isopropanol acetate / 0.5 h / Inert atmosphere 2: hydrogen / isopropanol acetate / 24 h / 35 °C / 15001.5 Torr View Scheme
参考文献
Nugent, Thomas C.; Negru, Daniela E.; El-Shazly, Mohamed; Hu, Dan; Sadiq, Abdul; Bibi, Ahtaram; Umar, M. Naveed
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2085 - 2092
反应条件
1: titanium(IV) isopropylate / ethyl acetate / 0.5 h / 20 °C 2: hydrogen / ethyl acetate; ethanol / 8 h / 24 °C / 6225.62 Torr View Scheme
参考文献
Nugent, Thomas C.; Marinova, Sofiya M.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-Z0768-FA, p. 153 - 166
反应条件
hydrogen Yield given;
参考文献
Eleveld, M. B.; Hogeveen, H.
Tetrahedron Letters, 1984 , vol. 25, # 45 p. 5187 - 5190
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 70 percent / 6 N aq. HCl / 3 h / 100 °C View Scheme
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
