(S)-(-)- α-甲基苄胺合成路线 (共 369 条)
反应条件
in xylene 24 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
参考文献
Kamer; Cleij; Nolte; Harada; Hezemans; Drenth
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1581 - 1587
反应条件
pyridine; acetic anhydride; trichlorophosphate Yield given. Multistep reaction;
参考文献
Alcock, Nathaniel W.; Pike, Graham A.; Richards, Christopher J.; Thomas, Susan E.
Tetrahedron: Asymmetry, 1990 , vol. 1, # 8 p. 531 - 534
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 87 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
参考文献
Uhan Corporation
Patent: US5990311 A1, 1999 ;
反应条件
in dimethyl sulfoxide T=50°C; 72 h;
参考文献
Couty, Francois; Evano, Gwilherm; Vargas-Sanchez, Monica; Bouzas, Gloria
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 9028 - 9031
反应条件
in water 0.333333 h; Sonication;
参考文献
Aparicio, David M.; Teran, Joel L.; Roa, Luis F.; Gnecco, Dino; Juarez, Jorge R.; Orea, Maria L.; Mendoza, Angel; Flores-Alamo, Marcos; Micouin, Laurent
Synthesis, 2011 , # 14 art. no. M11511SS, p. 2310 - 2320
反应条件
1: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 81 percent / LAH / tetrahydrofuran / 64 h View Scheme
参考文献
Nelson, Todd D.; Rosen, Jonathan D.; Brands, Karel M.J.; Craig, Bridgette; Huffman, Mark A.; McNamara, James M.
Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8917 - 8920
参考文献
Chan; Laughton; Queener; Stevens
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2555 - 2564