(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
triethylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Munagala, Gurunadham; Yempalla, Kushalava Reddy; Aithagani, Sravan Kumar; Kalia, Nitin Pal; Ali, Furqan; Ali, Intzar; Rajput, Vikrant Singh; Rani, Chitra; Chib, Reena; Mehra, Rukmankesh; Nargotra, Ami; Khan, Inshad Ali; Vishwakarma, Ram A.; Singh, Parvinder Pal
MedChemComm, 2014 , vol. 5, # 4 p. 521 - 527
反应条件
1: 86 percent / (NH4)2SO4 / 1.) 100 deg C, 5 h; 125 deg C, 19 h, 2.) TMSCl was added to complete conversion at 25 deg C, then 125 deg C, 12 h 2: 1.) n-BuLi, 2.) hexachloroethane / 1.) ether, hexane, 25 deg C, 24 h, 2.) ether, hexane, -40 deg C, 1 h View Scheme
参考文献
Polniaszek; Lichti
Synthetic Communications, 1992 , vol. 22, # 1 p. 171 - 178
反应条件
di-tert-butyl peroxide; [IndBox]Cu T=80°C; 24 h;
参考文献
US2011/213146 A1, ;
Page/Page column 3; 27 ;
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / Pd/C / tetrahydrofuran / 760 Torr View Scheme
参考文献
Uccello-Barretta; Bernardini; Balzano; Salvadori
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 123 - 129
反应条件
1: sec-phenethyl alcohol With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 16 h; 2: (S)-1-phenyl-ethylamine With sodium tris(acetoxy)borohydride in dichloromethane optical yield given as percent dechemoselective reaction;
参考文献
Guerin, Claire; Bellosta, Veronique; Guillamot, Gerard; Cossy, Janine
Organic Letters, 2011 , vol. 13, # 13 p. 3534 - 3537
反应条件
1: titanium(IV) isopropylate / isopropanol acetate / 0.5 h / Inert atmosphere 2: hydrogen / isopropanol acetate / 24 h / 35 °C / 15001.5 Torr View Scheme
参考文献
Nugent, Thomas C.; Negru, Daniela E.; El-Shazly, Mohamed; Hu, Dan; Sadiq, Abdul; Bibi, Ahtaram; Umar, M. Naveed
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2085 - 2092
反应条件
1: titanium(IV) isopropylate / ethyl acetate / 0.5 h / 20 °C 2: hydrogen / ethyl acetate; ethanol / 8 h / 24 °C / 6225.62 Torr View Scheme
参考文献
Nugent, Thomas C.; Marinova, Sofiya M.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-Z0768-FA, p. 153 - 166
反应条件
hydrogen Yield given;
参考文献
Eleveld, M. B.; Hogeveen, H.
Tetrahedron Letters, 1984 , vol. 25, # 45 p. 5187 - 5190
反应条件
1: 100 percent / ZnCl2 / toluene / 15 h / Heating 2: NaBH4 / methanol / 7 h / 0 °C 3: 99 percent / phthalic acid; H2 / Pd/C / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Chemistry Letters, 2004 , vol. 33, # 11 p. 1424 - 1425
反应条件
1: in diethyl ether T=20°C; 1 h; 2: With sodium acetate; acetic anhydride T=70°C; 6 h;
参考文献
Puerto Galvis, Carlos E.; Kouznetsov, Vladimir V.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 3 p. 407 - 411
