(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: ethanol / 3 h / Heating 2: 186 g / NaBH4 / 72 h / 20 °C View Scheme
参考文献
Ai, Lin; Xiao, Jichuan; Wang, Guo; Shen, Xiumin; Zhang, Cong
Synthetic Communications, 2006 , vol. 36, # 19 p. 2859 - 2875
反应条件
N,N'-dimethyl-N,N'-propyleneurea; sodium carbonate Heating;
参考文献
Huelgas, Gabriela; Bernes, Sylvain; Sanchez, Mario; Quintero, Leticia; Juaristi, Eusebio; Anaya de Parrodi, Cecilia; Walsh, Patrick J.
Tetrahedron, 2007 , vol. 63, # 51 p. 12655 - 12664
反应条件
in dichloromethane T=30°C; 12 h;
参考文献
Kita, Yasuyuki; Maeda, Hiroshi; Omori, Kana; Okuno, Takayuki; Tamura, Yasumitsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 23 p. 2999 - 3006
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
in isopropyl alcohol T=20°C; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/103221 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
in water T=0 - 80°C; Resolution of racemate; Purification / work up;
参考文献
WO2009/90663 A1, ;
Page/Page column 9 ;
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 100, p. 32 - 39
反应条件
1: 75 percent / K2CO3 / acetonitrile / 4 h / Heating 2: 69 percent / K2CO3 / H2O / 2.5 h / 0 °C View Scheme
参考文献
Manzano, Ruben; Rominger, Frank; Hashmi, A. Stephen K.
Organometallics, 2013 , vol. 32, # 7 p. 2199 - 2203
参考文献
Overby; Ingersoll
Journal of the American Chemical Society, 1951 , vol. 73, p. 3363,3364, 3365
反应条件
potassium carbonate in tetrahydrofuran 0 deg C, 2 h, then 25 deg C, 6 h;
参考文献
McQueney, Michael S.; Lee, Sheng-lian; Swartz, William H.; Ammon, Herman L.; Mariano, Patrick S.; Dunaway-Mariano, Debra
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7121 - 7130
