(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
hydrogenchloride in methanol; water T=0°C;
参考文献
Aton Pharma, Inc.
Patent: US2011/104765 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
potassium carbonate in water; toluene 20 h; Heating; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 6 p. 693 - 698
反应条件
1.1: 92 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2.1: n-BuLi; t-BuLi / hexane; tetrahydrofuran; pentane / -78 - -60 °C 2.2: 24 percent / hexane; tetrahydrofuran; pentane / -78 - 20 °C View Scheme
参考文献
McAlonan; Murphy; Nieuwenhuyzen; Reynolds; Sarma; Stevenso; Thompson
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 69 - 79
反应条件
potassium carbonate in water; toluene 20 h; Heating; Title compound not separated from byproducts;
参考文献
Hoshino, Jun'ichi; Hiraoka, Junko; Hata, Yasuo; Sawada, Seiji; Yamamoto, Yukio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 6 p. 693 - 698
反应条件
ueber mehrere Stufen;
参考文献
Journal of the American Chemical Society, , vol. 75, p. 5598,5601
反应条件
1: (S)-1-phenyl-ethylamine With sodium hydride in tetrahydrofuran 2: methyl iodide in tetrahydrofuran 8 h;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 10 p. 1261 - 1266
反应条件
1: 2: With lithium aluminium tetrahydride
参考文献
Tetrahedron Asymmetry, , vol. 20, # 20 p. 2331 - 2343
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
in ethyl acetate T=75 - 80°C; 0.166667 h;
参考文献
NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan
Patent: WO2014/9964 A1, 2014 ;
Location in patent: Page/Page column 17 ;
参考文献
Zhao, Qian-Yi; Yuan, Zhi-Liang; Shia, Min
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 4 p. 637 - 643
