(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: triethylamine / tetrahydrofuran / 2 h / 20 °C
2: acetone / 4 h / 20 °C
3: 17 percent / dilauroyl peroxide / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Torres-Murro, Jaime; Quintero, Leticia; Sartillo-Piscil, Fernando
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7691 - 7694
反应条件
in chloroform
T=23°C; 1 h;
参考文献
Miller, Shawn M.; Samame, Renzo A.; Rychnovsky, Scott D.
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20318 - 20321
反应条件
formic acid; resin (p-trityl-O-NH2); benzotriazol-1-ol; dicyclohexyl-carbodiimide
1.) THF, 60 deg C, 6 h; 2.) DMF 6 h; 3.) THF 1 h;; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bauer, Udo; Ho, Wen-Bin; Koskinen, Ari M.P.
Tetrahedron Letters, 1997 , vol. 38, # 41 p. 7233 - 7236
反应条件
sodium carbonate in acetonitrile
T=20°C; 4 h;
参考文献
Rodriguez, Veronica; Sanchez, Mario; Quintero, Leticia; Sartillo-Piscil, Fernando
Tetrahedron, 2004 , vol. 60, # 48 p. 10809 - 10815
参考文献
Galeazzi, Roberta; Geremia, Silvano; Mobbili, Giovanna; Orena, Mario
Tetrahedron Asymmetry, 1996 , vol. 7, # 12 p. 3573 - 3584
反应条件
in tetrahydrofuran
24 h; Ambient temperature;
参考文献
Nakanishi, Saburo; Okamoto, Kenji; Yamaguchi, Hiroshi; Takata, Toshikazu
Synthesis, 1998 , # 12 p. 1735 - 1741
参考文献
Basha; McClellan; DeBernardis
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5469 - 5472
反应条件
in N,N-dimethyl-formamide
参考文献
Fernandez, Isabelle; Munoz, Luis
Tetrahedron Asymmetry, 2006 , vol. 17, # 17 p. 2548 - 2557
反应条件
1: 75 percent / CH2Cl2 / 5 h / Ambient temperature
2: 91 percent / Et3N, DMAP / ethyl acetate / 1 h / 0 °C
3: Mn(OAc)3*2H2O, Cu(OAc)2*H2O / acetic acid / 12 h / Ambient temperature
4: 77 percent / aq. NaCl / dimethylformamide / 3 h / Heating
5: 1.) 9-BBN, 2.) 30percent aq. H2O2, 2 M aq. NaOH / 1.) THF, 20 deg C, overnight, 2.) THF, 12 h
6: pyridinium dichromate / dimethylformamide / 1 h / Ambient temperature
7: methanol; diethyl ether
8: 56 percent / BH3*THF / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Galeazzi, Roberta; Mobbili, Giovanna; Orena, Mario
Tetrahedron, 1996 , vol. 52, # 3 p. 1069 - 1084
反应条件
in ethanol
T=0 - 20°C; Yield given;
参考文献
Page, Philip C. Bulman; Rassias, Gerasimos A.; Bethell, Donald; Schilling, Mark B.
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2774 - 2777
