(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: dicyclohexylcarbodiimide, N-hydroxysuccinimide
2: 5percent palladium on charcoal / methanol / 10 °C / other solvents, other temperatures
View Scheme
参考文献
Harada, Kaoru; Munegumi, Toratane; Nomoto, Shinya
Tetrahedron Letters, 1981 , vol. 22, p. 111 - 114
参考文献
Lewis, Frank W.; Eichler, Matthias C.; Grayson, David H.
Synlett, 2009 , # 12 p. 1923 - 1928
参考文献
Deshpande, Sudhindra H.; Kelkar, Ashutosh A.; Gonnade, Rajesh G.; Shingote, Savita K.; Chaudhari, Raghunath V.
Catalysis Letters, 2010 , vol. 138, # 3-4 p. 231 - 238
参考文献
Lai; Shi; Gong; Dai
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4775 - 4777
反应条件
1.1: 12 h / Heating
2.1: 90 percent / sodium borohydride / methanol / 2 h / 20 °C
3.1: TMEDA; n-butyllithium / tetrahydrofuran; hexane / 2 h / 20 °C
3.2: 50 percent / iodine / tetrahydrofuran; hexane / 12 h / 20 °C
4.1: 50 percent / triethylamine / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Leleu, Stephane; Papamicael, Cyril; Marsais, Francis; Dupas, Georges; Levacher, Vincent
Tetrahedron Asymmetry, 2004 , vol. 15, # 24 p. 3919 - 3928
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer
T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
1: With magnesium sulfate; 4-methoxy-benzaldehyde in dichloromethane
T=20°C;
2: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 4 h;
3: With hydroxylamine hydrochloride; oxalic acid
more than 3 stages;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4067 A2, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
1: MgSO4 / methanol
2: NaBH4 / methanol / 20 °C
3: NaNH2 / toluene / Heating
View Scheme
参考文献
Kelleher, Fintan; Kelly, Sinead
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5247 - 5250
反应条件
1: MgSO4 / methanol
2: NaBH4 / methanol / 20 °C
3: NaNH2 / toluene / Heating
View Scheme
参考文献
Kelleher, Fintan; Kelly, Sinead
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5247 - 5250
反应条件
1.1: n-BuLi / diethyl ether; hexane / 1 h / -35 °C
2.1: n-BuLi / diethyl ether; hexane / -35 - 20 °C
2.2: 1.22 g / diethyl ether; hexane / 7 h / -35 - 20 °C
View Scheme
参考文献
Huang, Jia-Di; Hu, Xiang-Ping; Duan, Zheng-Chao; Zeng, Qing-Hen; Yu, Sai-Bo; Deng, Jun; Wang, Dao-Yong; Zheng, Zhuo
Organic Letters, 2006 , vol. 8, # 19 p. 4367 - 4370
