(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: (S)-1-phenyl-ethylamine With n-butyllithium; chloro-trimethyl-silane in diethyl ether
T=0°C; Inert atmosphere;
2: chloro-diphenylphosphine With n-butyllithium in diethyl ether
T=-30°C; Inert atmosphere;
参考文献
Zhou, Xiao-Mao; Huang, Jia-Di; Luo, Li-Bin; Zhang, Cheng-Lu; Zheng, Zhuo; Hu, Xiang-Ping
Tetrahedron Asymmetry, 2010 , vol. 21, # 4 p. 420 - 424
反应条件
in diethyl ether
1.) 1 h, 60 deg C, 2.) 12 h, 20 deg C;
参考文献
Molines, Huguette; Wakselman, Claude
Synthesis, 1984 , # 10 p. 838 - 839
反应条件
1: Et2SnCl2 / benzene / 2 h / Heating
2: dimethylformamide / 48 h / Ambient temperature
View Scheme
参考文献
Karchava, Alexander V.; Yurovskaya, Marina A.; Wagner, Thomas R.; Zybailov, Boris L.; Bundel, Yuri G.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 12 p. 2895 - 2898
反应条件
4 A molecular sieve in toluene
Ambient temperature;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
in ethanol
T=0 - 80°C; Inert atmosphere;
参考文献
Mayani, Vishal J.; Abdi, Sayed H. R.; Kureshy, Rukhsana I.; Khan, Noor-Ul H.; Das, Anjan; Bajaj, Hari C.
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6191 - 6195
反应条件
zinc diacetate; magnesium sulfate in dichloromethane
T=20°C; 16 h;
参考文献
Vohra, Ramandeep Kaur; Renaud, Jean-Luc; Bruneau, Christian
Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 11 p. 1943 - 1952
反应条件
hydrogen; palladium dichloride in 1,4-dioxane
Rate constant;
参考文献
Kaigorodova, L. N.; Levitina, E. S.; Karpeiskaya, E. I.; Klabunovskii, E. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 747 - 749
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 4 p. 813 - 816
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer
T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
1: 78 percent / neat (no solvent) / 2 h / 180 °C
2: 85 percent / LiEt3BH / tetrahydrofuran / -78 °C
View Scheme
参考文献
Polniaszek, Richard P.; Belmont, Stephen E.; Alvarez, Ramon
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 215 - 223
反应条件
in benzene
Kabachnik-Field reactions; 2 h; Heating;
参考文献
Dimukhametov, Mudaris N.; Bayandina, Evgenia V.; Davydova, Elena Yu.; Gubaidullin, Aidar T.; Litvinov, Igor A.; Alfonsov, Vladimir A.
Mendeleev Communications, 2003 , vol. 13, # 3 p. 150 - 151
