(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
Chromobacterium violaceum ATA-114 1100708MW; ωTA ATA-117 102907WW; pyridoxal 5'-phosphate; pentan-3-one T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Engstroem, Karin; Johnston, Eric V.; Verho, Oscar; Gustafson, Karl P. J.; Shakeri, Mozaffar; Tai, Cheuk-Wai; Baeckvall, Jan-E.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14006 - 14010
Angew. Chem., 2013 , vol. 52-125, # 52 p. 14256 - 14260
反应条件
hydroxylammonium acetate in ethanol 10 h; Ambient temperature; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yuanwei, Chen; Aiqiao, Mi; Xun, Xiao; Yaozhong, Jiang
Synthetic Communications, 1989 , vol. 19, # 7,8 p. 1423 - 1430
反应条件
1: 82 percent / (1R,4R)-2,5-dibenzylbicyclo[2.2.2]octa-2,5-diene; [RhCl(C2H4)2]2 / dioxane; hexane / 3 h / 50 °C 2: 79 percent / lithium; liq. ammonia / tetrahydrofuran / 0.25 h / -78 °C View Scheme
参考文献
Nishimura, Takahiro; Yasuhara, Yuichi; Hayashi, Tamio
Organic Letters, 2006 , vol. 8, # 5 p. 979 - 981
反应条件
1: NaBH4+tetrahydrofurfuryl alcohol / (S,S)-Co(II) complex catalyst (C48H54N2O4Co) / ethanol; CHCl3 / 4 h / 0 °C 2: HCl / methanol / 3 h / 25 °C View Scheme
参考文献
Sugi, Kiyoaki D.; Nagata, Takushi; Yamada, Tohru; Mukaiyama, Teruaki
Chemistry Letters, 1997 , # 6 p. 493 - 494
反应条件
1: phosphate buffer (pH 7.0) / acetone / 72 h / lipase B from Candida antarctica in the immobilised form Novozym 435 2: OH(-), H2O View Scheme
参考文献
Chapman, Daniel T.; Crout, David H. G.; Mahmoudian, Mahmoud; Scopes, David I. C.; Smith, Paul W.
Chemical Communications, 1996 , # 21 p. 2415 - 2416
反应条件
1: 70 percent / lithium aluminium hydride / diethyl ether / 3.25 h / Heating 2: conc. HCl, hydrogen / 10percent Pd-carbon / ethanol / 12 h / 45 °C / 4045.3 Torr View Scheme
参考文献
Takahashi; Tomita; Noguchi
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3387 - 3391
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
反应条件
1: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 2: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 3: sodium ethoxide / ethanol / 1 h / 40 °C 4: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
