2-氨基-6-羟基苯并噻唑合成路线 （共 15 条）
反应条件
hydrogen bromide in water T=107°C; 5 h;
参考文献
WO2010/54058 A1, ;
Page/Page column 73-75 ;
WO 2010/054058 A1
反应条件
1: With water; hydrogen bromide in acetic acid T=150°C; 0.0555556 h; Microwave; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
US2007/93488 A1, ;
Page/Page column 7 ;
反应条件
sodium hydrogencarbonate in methanol; dichloromethane; water
反应条件
sodium acetate in water
参考文献
US2007/232604 A1, ;
Page/Page column 39 ;
反应条件
bromine; acetic acid T=-10 - 0°C; 4 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 1 - 13
反应条件
1: With bromine in chloroform T=0 - 5°C; Reflux; 2: With ammonia in water
参考文献
Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148
反应条件
hydrogenchloride in ethanol
参考文献
Journal of Organic Chemistry, , vol. 35, p. 4103 - 4108
反应条件
1.1: hydrogenchloride / water / 0.5 h / Reflux 1.2: 4 h / 20 °C / Reflux 2.1: bromine / chloroform / 0 - 5 °C / Reflux View Scheme
参考文献
Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in acetonitrile Reflux;
参考文献
Liu, Da-Chuan; Deng, Xian-Qing; Wang, Shi-Ben; Quan, Zhe-Shan
Archiv der Pharmazie, 2014 , vol. 347, # 4 p. 268 - 275
反应条件
1.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / |Reflux 2.1: sulfuric acid / ethylene glycol; water / 0.5 h / 80 °C 2.2: 5 h / 140 °C View Scheme
参考文献
Liu, Da-Chuan; Deng, Xian-Qing; Wang, Shi-Ben; Quan, Zhe-Shan
Archiv der Pharmazie, 2014 , vol. 347, # 4 p. 268 - 275
