2-氨基-6-羟基苯并噻唑合成路线 （共 15 条）
反应条件
1.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / |Reflux
2.1: sulfuric acid / ethylene glycol; water / 0.5 h / 80 °C
2.2: 5 h / 140 °C
View Scheme
参考文献
Liu, Da-Chuan; Deng, Xian-Qing; Wang, Shi-Ben; Quan, Zhe-Shan
Archiv der Pharmazie, 2014 , vol. 347, # 4 p. 268 - 275
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in acetonitrile
Reflux;
参考文献
Liu, Da-Chuan; Deng, Xian-Qing; Wang, Shi-Ben; Quan, Zhe-Shan
Archiv der Pharmazie, 2014 , vol. 347, # 4 p. 268 - 275
反应条件
1: isopropyl alcohol / 24 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 85 °C
View Scheme
参考文献
AMBIT BIOSCIENCES CORP.; GROSS, Timothy, David; PRASAD, Achampeta, Rathan; CITINENI, Janakiram, Rao
Patent: WO2011/56939 A1, 2011 ;
反应条件
1: isopropyl alcohol / 24 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 85 °C
3: ammonium chloride; iron / ethanol / 5 h / Reflux
View Scheme
参考文献
AMBIT BIOSCIENCES CORP.; GROSS, Timothy, David; PRASAD, Achampeta, Rathan; CITINENI, Janakiram, Rao
Patent: WO2011/56939 A1, 2011 ;
反应条件
pyridine
T=25°C; 23 h; Product distribution / selectivity;
参考文献
AVENTIS PHARMA S.A.
Patent: US2008/194555 A1, 2008 ;
Location in patent: Page/Page column 20 ;
