3-甲基吲哚-2-甲酸乙酯合成路线 （共 26 条）
反应条件
perchloric acid; hydrogen; palladium on activated charcoal in ethanol T=50°C; P=3620.04 Torr; 3 h;
参考文献
Wadia, M. S.; Mali, R. S.; Tilve, S. G.; Yadav, V. J.
Synthesis, 1987 , # 4 p. 401 - 404
反应条件
copper(l) iodide in dimethyl sulfoxide T=70°C; 0.166667 h; Ionic liquidInert atmosphereMicrowave irradiationSealed tube;
参考文献
Gu, Lijun; Li, Xiangguang
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 11 p. 2036 - 2039
反应条件
1: With dirhodium tetraacetate in toluene T=80°C; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=20°C; Further stages.;
参考文献
Nakamura, Yoshinori; Ukita, Tatsuzo
Organic Letters, 2002 , vol. 4, # 14 p. 2317 - 2320
反应条件
1: 3-Methylindole-2-carboxylic acid With tert.-butyl lithium in tetrahydrofuran T=-78 - -35°C; 0.166667 h; 2: chloroformic acid ethyl ester in tetrahydrofuran T=-78°C; 0.333333 h;
参考文献
Jong, Ling; Chao, Wan-Ru
Patent: US2004/43965 A1, 2004 ;
Location in patent: Page/Page column 21-22 ;
反应条件
copper(l) iodide in dimethyl sulfoxide T=20°C; 6 h; Inert atmosphere;
参考文献
Cai, Qian; Li, Zhengqiu; Wei, Jiajia; Ha, Chengyong; Pei, Duanqing; Ding, Ke
Chemical Communications, 2009 , # 48 p. 7581 - 7583
反应条件
copper(l) iodide in dimethyl sulfoxide T=60°C; 0.166667 h; Ionic liquidInert atmosphereMicrowave irradiationSealed tube;
参考文献
Gu, Lijun; Li, Xiangguang
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 11 p. 2036 - 2039
反应条件
toluene-4-sulfonic acid Heating / reflux;
参考文献
FibroGen, Inc.
Patent: US2008/4309 A1, 2008 ;
Location in patent: Page/Page column 64 ;
反应条件
triethyl phosphite T=170°C; 3 h;
参考文献
Mali; Yadav
Synthesis, 1984 , vol. NO. 10, p. 862 - 865
反应条件
1: 65 percent / CH3COOH / methanol / 4 h / Heating 2: 84 percent / H2, HClO4 / 10percent Pd-C / ethanol / 3 h / 50 °C / 3620.04 Torr View Scheme
参考文献
Wadia, M. S.; Mali, R. S.; Tilve, S. G.; Yadav, V. J.
Synthesis, 1987 , # 4 p. 401 - 404
反应条件
ethanol; sulfuric acid
参考文献
Kitano, Masafumi; Kojima, Atsuyuki; Nakano, Kazuhiro; Miyagishi, Akira; Noguchi, Tsuyoshi; Ohashi, Naohito
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1538 - 1548
