3-甲基吲哚-2-甲酸乙酯合成路线 （共 26 条）
反应条件
Cyclization; 4 h; Heating;
参考文献
Fretz, Heinz; Gaugler, Markus; Schneider, Joseph
Helvetica Chimica Acta, 2000 , vol. 83, # 6 p. 1145 - 1150
反应条件
Cyclization; 6 h; Heating;
参考文献
Fretz, Heinz; Gaugler, Markus; Schneider, Joseph
Helvetica Chimica Acta, 2000 , vol. 83, # 6 p. 1145 - 1150
反应条件
1: lithium alanate; diethyl ether 2: potassium permanganate; acetone View Scheme
参考文献
Taylor
Helvetica Chimica Acta, 1950 , vol. 33, p. 164,167
Helvetica Chimica Acta, 1954 , vol. 34, p. 787
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
反应条件
N-bromosuccinmide; trifluoroacetic acid in tetrahydrofuran
T=20°C; 0.0833333 h;
参考文献
Jong, Ling; Chao, Wan-Ru
Patent: US2004/43965 A1, 2004 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: ethyl 3-methyl-1H-indole-2-carboxylate With sodium hydride in N,N-dimethyl-formamide
T=20°C; Metallation; 1 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; Alkylation; 5 h;
参考文献
Kitano, Masafumi; Kojima, Atsuyuki; Nakano, Kazuhiro; Miyagishi, Akira; Noguchi, Tsuyoshi; Ohashi, Naohito
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1538 - 1548
