4-氯-7-羟基-6-甲氧基喹啉-3-甲腈合成路线 （共 13 条）
反应条件
triphenylphosphine; diethylazodicarboxylate
Mitsunobu reaction;
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
triphenylphosphine; diethylazodicarboxylate in dichloromethane
T=20°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/5284 A1, 2004 ;
Location in patent: Page 72 ;
WO 2004/005284 A1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0°C; Mitsunobu conditions; 0.25 h;
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
