(1R)-(-)-薄荷基乙醛酸合成路线 （共 9 条）
反应条件
1: With sulfuric acid in cyclohexane; water T=80 - 85°C; 4 h; 2: With formaldehyd in water T=25 - 35°C; pH=5; 1 h; 3: With sodium carbonate in water T=25 - 35°C; pH=7.5; 6 h;
参考文献
RANBAXY LABORATORIES LIMITED; KSHIRSAGAR, Prakash Bhimaji; BHOGE, Satish Manohar; RICHHARIYA, Santosh; SINGH, Kaptan
Patent: WO2011/107920 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
tri-n-butyl-tin hydride in benzene Heating;
参考文献
Blanco, Jose M.; Caamano, Olga; Fernandez, Franco; Garcia-Mera, Xerardo; Lopez, Carmen; Rodriguez-Borges, Jose E.; Hergueta, Antonio R.
Synthesis, 1998 , # 11 p. 1590 - 1592
反应条件
1: CHCl3 / 2 h / Ambient temperature 2: Bu3SnH / Pd(Ph3P)4 / 1.) PhH, r.t., 2 h, 2.) PhH, CH2Cl2, reflux, 1 h View Scheme
参考文献
Ebeling, Sabine C.; Matthies, D.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 3 p. 271 - 272
反应条件
phosphorus pentoxide; dimethyl sulfoxide in dichloromethane Ambient temperature;
参考文献
Ebeling, Sabine C.; Matthies, D.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 3 p. 271 - 272
反应条件
pyridinium p-toluenesulfonate in benzene 4 h; Heating;
参考文献
Blanco, Jose M.; Caamano, Olga; Fernandez, Franco; Garcia-Mera, Xerardo; Lopez, Carmen; Rodriguez-Borges, Jose E.; Hergueta, Antonio R.
Synthesis, 1998 , # 11 p. 1590 - 1592
反应条件
tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) 1.) PhH, r.t., 2 h, 2.) PhH, CH2Cl2, reflux, 1 h; Title compound not separated from byproducts;
参考文献
Blanco, Jose M.; Caamano, Olga; Fernandez, Franco; Garcia-Mera, Xerardo; Lopez, Carmen; Rodriguez-Borges, Jose E.; Hergueta, Antonio R.
Synthesis, 1998 , # 11 p. 1590 - 1592
反应条件
sodium acetate in N,N-dimethyl-formamide
参考文献
Jurczak,J.; Zamojski,A.
Roczniki Chemii, 1970 , vol. 44, p. 2257 - 2260
反应条件
1: AgNO3 / acetonitrile 2: NaOAc*3H2O / dimethylformamide View Scheme
参考文献
Jurczak,J.; Zamojski,A.
Roczniki Chemii, 1970 , vol. 44, p. 2257 - 2260
反应条件
sulfuric acid; toluene-4-sulfonic acid Multistep reaction. Yields of byproduct given;
参考文献
Laugraud, Sylvain; Guingant, Andre; d'Angelo, Jean
Journal of Organic Chemistry, 1987 , vol. 52, # 21 p. 4788 - 4790
