alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
in tetrahydrofuran
T=20°C; 24 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Crombie, Leslie; Hardy, Robert; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1373 - 1380
反应条件
(i) NaH, THF, (ii) /BRN= 743112/, KI, acetone, (iii) KOH; Multistep reaction;
参考文献
Lawson,J.E. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 383 - 386
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 100 percent / W-2 Raney Ni / ethanol / 0.5 h / Heating
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: HCO2Na*2H2O; sodium dodecyl sulfate; cetyltrimethylammonium bromide / [RhCl2(Cp*)]2; (R,R)-TsDPEN / H2O / 1 h / 28 °C
2: HCO2Na*2H2O; cetyltrimethylammonium bromide / [{(R,R)-TsDPEN}RuCl(p-cymene)] / H2O / 20 h / 28 °C
View Scheme
参考文献
Wang, Fei; Liu, Hui; Cun, Linfeng; Zhu, Jin; Deng, Jingen; Jiang, Yaozhong
Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9424 - 9429
反应条件
1: 2-bromo-4'-methoxy-acetophenone With thiamine hydrochloride in ethanol
T=20°C; 0.25 h; Green chemistry;
2: salicylaldehyde in ethanol
T=20°C; 1.5 h; Green chemistry;
参考文献
Mishra, Priya; Singh, Sarita; Ankit, Preyas; Fatma, Shahin; Singh, Divya; Singh, Jagdamba
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1070 - 1076
反应条件
1-amino-2-oxo-4,6-diphenylpyridine
DMSO, 1.) 10 h, room temp., 2.) 6 h, 100 deg C; Yield given. Multistep reaction;
参考文献
Alajarin, M.; Fresneda, P. M.; Molina, P.
Synthesis, 1980 , # 10 p. 844 - 845
反应条件
tris(n-butyl)phosphine oxide in benzene
T=25°C; 1 h;
参考文献
Yasuda, Makoto; Oh-hata, Tatsuhiro; Shibata, Ikuya; Baba, Akio; Matsuda, Haruo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 7 p. 859 - 866
反应条件
tris(n-butyl)phosphine oxide
1 h; Ambient temperature;
参考文献
Baba, Akio; Yasuda, Makoto; Yano, Katsunori; Shibata, Ikuya; Matsuda, Haruo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 3205 - 3207
参考文献
Heck,R.F.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2205 - 2208
反应条件
1: With sodium benzenesulfinate resin; tetra-(n-butyl)ammonium iodide; potassium iodide in N,N-dimethyl-formamide
T=20°C; 24 h;
2: 2-bromo-4'-methoxy-acetophenone With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 48 h;
3: With hydrazine in 1,4-dioxane; ethanol
T=20°C; 12 h;
参考文献
Chen, Yu; Lam, Yulin; Lee, Soo-Ying
Chemistry Letters, 2001 , # 3 p. 274 - 275
