alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
in N,N-dimethyl-formamide
T=120°C; 0.333333 h; microwave irradiation;
参考文献
Xiang, Jason; Ipek, Manus; Suri, Vipin; Tam, May; Xing, Yuzhe; Huang, Nelson; Zhang, Yanling; Tobin, James; Mansour, Tarek S.; McKew, John
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4396 - 4405
参考文献
Bonano, Vivian I.; Yokoyama-Yasunaka, Jenicer K.U.; Miguel, Danilo C.; Jones, Scott A.; Dodge, Jeffrey A.; Uliana, Silvia R.B.
Chemical Biology and Drug Design, 2014 , vol. 83, # 3 p. 289 - 296
反应条件
1: NH2OH*H2SO4 / methanol; H2O
2: (i) TsOH, (ii) /BRN= 610776/, Et2O
3: aq. HBr / CHCl3
4: Et3N / methanol
View Scheme
参考文献
Hassner,A.; Alexanian,V.
Journal of Organic Chemistry, 1979 , vol. 44, p. 3861 - 3864
参考文献
Bahner et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 1472
反应条件
potassium fluoride; ZnF2; tetrabutyl ammonium fluoride in acetonitrile
T=80°C; 10 h;
参考文献
Chen, Zizhan; Zhu, Wei; Zheng, Zubiao; Zou, Xinzhuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 340 - 344
反应条件
tetrabutylammonium hydrogen bifluoride in tetrahydrofuran
Heating;
参考文献
Fuglseth, Erik; Thvedt, Thor Hakon Krane; Moll, Maria Forde; Hoff, Bard Helge
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7318 - 7323
反应条件
1.1: triethylamine / toluene / 20 °C
2.1: methanol; water / 1 h / 20 °C
2.2: 20 °C / pH 7 - 8
3.1: dichloromethane / Reflux; Inert atmosphere
View Scheme
参考文献
An, Xiao-Lei; Chen, Jia-Rong; Li, Chang-Feng; Zhang, Fu-Gen; Zou, You-Quan; Guo, Ying-Cen; Xiao, Wen-Jing
Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2258 - 2265
参考文献
Bahner et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3499
参考文献
Bahner et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4011
反应条件
1.1: acetone / 1 h / Heating
1.2: 99 percent / aq. K2CO3 / 5 h
2.1: NaSEt / dimethylformamide / 100 °C
View Scheme
参考文献
Chai, Wenying; Breitenbucher, J. Guy; Kwok, Annette; Li, Xiaobing; Wong, Victoria; Carruthers, Nicholas I.; Lovenberg, Timothy W.; Mazur, Curt; Wilson, Sandy J.; Axe, Frank U.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1767 - 1770
