alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate in dichloromethane
T=25 - 30°C; 4 h;
参考文献
Fan, Mingjin; Yan, Zeyi; Liu, Weimin; Liang, Yongmin
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 8204 - 8207
反应条件
1: tetrahydrofuran / 0.5 h / 25 °C
2: 52 percent / K2CO3 / acetonitrile / 25 °C
View Scheme
参考文献
Fan, Mingjin; Guo, Lina; Liu, Xueyuan; Liu, Weimin; Liang, Yongmin
Synthesis, 2005 , # 3 art. no. F13204SS, p. 391 - 396
反应条件
in ethanol
2 h; Heating;
参考文献
Gillon, David W.; Forrest, Ian J.; Meakins, G. Denis; Tirel, Malcolm D.; Wallis, John D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 341 - 348
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
3: BBr3 / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
3: BBr3 / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
1: 97 percent / NaN3 / dimethylsulfoxide / 0.12 h / Ambient temperature
2: 1.) lithium diisopropyl amide, HMPA / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C to RT
3: 74 percent / cyclohexane / 24 h / 90 °C
View Scheme
参考文献
Takeuchi, Hisato; Yanagida, Shun-ichi; Ozaki, Tooru; Hagiwara, Satoshi; Eguchi, Shoji
Journal of Organic Chemistry, 1989 , vol. 54, # 2 p. 431 - 434
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: AlCl3 / CH2Cl2 / 1.5 h / 27 - 29 °C
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
