alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
sodium ethanolate in ethanol; acetone
1.) 2 h, 2.) overnight;
参考文献
Surpateanu, G.; Lungu, N. C.; Avarvari, N.; Lablache-Combier, A.; Grandclaudon, P.; Couture, A.
Journal de Chimie Physique et de Physico-Chimie Biologique, 1994 , vol. 91, # 10 p. 1648 - 1657
反应条件
1: 1,2-dimethoxy-ethane / 48 h / Heating
2: sodium nitrite / acetic acid
3: H2 / Raney nickel
View Scheme
参考文献
Rival; Grassy; Michel
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1170 - 1176
反应条件
sodium ethanolate in ethanol; acetonitrile
2 h; Ambient temperature;
参考文献
Kataoka, Tadashi; Tomoto, Akihiko; Shimizu, Hiroshi; Hori, Mikio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2913 - 2920
反应条件
1: 90 percent / NaOEt / ethanol; acetonitrile / 2 h / Ambient temperature
2: 86.8 percent / NaIO4 / H2O; methanol / 24 h / Ambient temperature
View Scheme
参考文献
Kataoka, Tadashi; Tomoto, Akihiko; Shimizu, Hiroshi; Hori, Mikio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2913 - 2920
反应条件
sodium hydroxide in ethanol
6 h;
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Tetrahedron, 1984 , vol. 40, # 23 p. 4941 - 4946
反应条件
in N,N-dimethyl-formamide
T=150°C; Hantzsch thiazole synthesis; P=4500.45 Torr; 0.0625 h; Inert atmosphere;
参考文献
Pagano, Nicholas; Heil, Marintha L.; Cosford, Nicholas D. P.
Synthesis (Germany), 2012 , vol. 44, # 16 p. 2537 - 2546
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
1: N,N-dimethylaniline / 170 °C
2: 1.) Na/liquid NH3 / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min
3: BBr3 / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 5 h;
参考文献
Apodaca, Richard; Barbier, Ann J.; Carruthers, Nicholas I.; Gomez, Leslie A.; Keith, John M.; Lovenberg, Timothy W.; Wolin, Ronald L.
Patent: US2006/293316 A1, 2006 ;
Location in patent: Page/Page column 60 ;
US 20060293316 A1
反应条件
1: K2CO3 / acetone / Heating
2: p-toluenesulfonic acid / benzene / Heating
View Scheme
参考文献
Liu, Guixia; Lu, Xiyan
Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16504 - 16505
