alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=20°C; 0.266667 h; Inert atmosphere;
参考文献
Singh, Santosh; Singh, Pankaj; Rai, Vijai K.; Kapoor, Ritu; Yadav, Lal Dhar S.
Tetrahedron Letters, 2011 , vol. 52, # 1 p. 125 - 128
反应条件
1: 70 percent / 2percent NaOH aq / ethanol
2: 45 percent / conc HCl/60percent HClO4 / methanol / Heating
View Scheme
参考文献
Hercules Incorporated
Patent: US4265807 A1, 1981 ;
参考文献
Lafontaine, Jennifer A.; Day, Robert F.; Dibrino, Joe; Hadcock, John R.; Hargrove, Diane M.; Linhares, Michael; Martin, Kelly A.; Maurer, Tristan S.; Nardone, Nancy A.; Tess, David A.; DaSilva-Jardine, Paul
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5245 - 5250
反应条件
in formic acid
2.75 h; Heating;
参考文献
Whitney, Scott E.; Winters, Michael; Rickborn, Bruce
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 929 - 935
参考文献
Khan; Saify; Ahmed; Saeed; Schick; Kohlbau; Voelter
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 10 p. 915 - 924
反应条件
potassium hydroxide in various solvent(s)
Ambient temperature;
参考文献
Shvedov, V. I.; Safonova, O. A.; Bulanova, T. I.; Il'ina, A. S.; Shvarts, G. Ya.; et al.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 11 p. 794 - 798
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 11 p. 67 - 71
反应条件
in water; acetone
T=35°C; Rate constant;
参考文献
Srinivasan, C.; Shunmugasundaram, A.; Roja, M.; Arumugam, N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 6 p. 555 - 557
Title/Abstract Full Text Show Details
Srinavasan, Chockalingam; Shunmugasundaram, Arunachalam; Arumugam, Natesan
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 17 - 20
反应条件
potassium carbonate in acetone
T=80°C; 2 h;
参考文献
Lee, Jin Ho; Kim, Myungock; Kim, Ikyon
Journal of Organic Chemistry, 2014 , vol. 79, # 13 p. 6153 - 6163
反应条件
1: potassium carbonate / 50 - 60 °C
2: tetrahydrofuran / 8 h / |Irradiation
View Scheme
参考文献
Ishida, Naoki; Necas, David; Shimamoto, Yasuhiro; Murakami, Masahiro
Chemistry Letters, 2013 , vol. 42, # 9 p. 1076 - 1078
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
5: AlCl3 / 1,2-dichloro-ethane / 1 h
6: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
