alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
sodium tetrahydroborate in ethanol; water chemoselective reaction;
参考文献
Letters in Organic Chemistry, , vol. 8, # 8 p. 592 - 595
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C 3: 71 percent / pyridine hydrochloride / 6 h / 220 °C View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: NaOH / ethanol 2: polyphosphoric acid / Heating View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
potassium hydroxide; PPA in ethanol; water; ethyl acetate
参考文献
ELI LILLY AND COMPANY
Patent: EP826682 A1, 1998 ;
反应条件
potassium hydroxide in ethanol; water; Petroleum ether
参考文献
ELI LILLY AND COMPANY
Patent: EP819686 A1, 1998 ;
反应条件
1: 94 percent / sodium / ethanol 2: 13 percent / chloranil / dioxane / 4 h / 60 °C 3: 95 percent / methanol / 0.5 h / Heating View Scheme
参考文献
MacKenzie, Neil E.; Thomson, Ronald H.; Greenhalgh, Colin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2923 - 2932
反应条件
1: ammonium thiocyanate With montmorillonite K10 clay in acetone T=20°C; 0.666667 h; 2: 2-bromo-4'-methoxy-acetophenone T=20°C; 0.00833333 h; Neat (no solvent)Grinding;
参考文献
Meshram; Thakur, Pramod B.; Madhu Babu; Bangade, Vikas M.
Tetrahedron Letters, 2012 , vol. 53, # 14 p. 1780 - 1785
反应条件
tetrabutylammomium bromide in water T=20°C; 0.416667 h;
参考文献
Sayyahi, Soheil; Saghanezhad, Jafar
Chinese Chemical Letters, 2011 , vol. 22, # 3 p. 300 - 302
反应条件
in ethanol 2 h; Heating;
参考文献
Delbecq, Frederic; Cordonnier, Guy; Pommery, Nicole; Barbry, Didier; Henichart, Jean-Pierre
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1119 - 1121
反应条件
1-methyl-1H-imidazole 2 h;
参考文献
Palsuledesai, Charuta C.; Murru, Siva; Sahoo, Santosh K.; Patel, Bhisma K.
Organic Letters, 2009 , vol. 11, # 15 p. 3382 - 3385
