2-溴-1-(3,4-二甲基苯基)-乙酮合成路线 （共 5 条）
反应条件
pyridinium tribromide; trifluoroacetic acid in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
PIERRE FABRE MEDICAMENT; PEREZ, Michel; LAMOTHE, Marie; JUNQUERO, Didier; RIVAL, Yves
Patent: WO2010/100139 A1, 2010 ;
Location in patent: Page/Page column 94-95 ;
WO 2010/100139 A1
反应条件
carbon disulfide; aluminium trichloride
参考文献
Jacobs; Heidelberger
Journal of Biological Chemistry, 1915 , vol. 21, p. 445
反应条件
in xylene T=60°C; Ea; Thermodynamic data;
参考文献
Richardson, William H.; Stiggal-Estberg, Diana L.; Chen, Zhangping; Baker, John C.; Burns, David M.; Sherman, David G.
Journal of Organic Chemistry, 1987 , vol. 52, # 14 p. 3143 - 3150
反应条件
1: 94 percent / acetonitrile / 1) RT, 2h, 2) 70 deg C
2: 97 percent / 6N HCl / 0.5 h / 120 °C
View Scheme
参考文献
Yinglin, Han; Hongwen, Hu
Synthesis, 1990 , # 7 p. 615 - 618
反应条件
hydrogenchloride
1a) EtOH, RT, 2h, 1b) 50 deg C, 30 min, 2) 30 min, reflux; Yield given. Multistep reaction;
参考文献
Yinglin, Han; Hongwen, Hu
Synthesis, 1990 , # 7 p. 615 - 618
