2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
参考文献
Lapkin et al.
Sb. Statei Obshch. Khim., 1953 , p. 823,827
Chem.Abstr., 1955 , p. 6876
反应条件
tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=20°C; 48 h;
参考文献
EXXONMOBIL CHEMICAL PATENTS INC.
Patent: WO2007/70038 A1, 2007 ;
Location in patent: Page/Page column 83 ;
反应条件
Pd(dba)2 in tetrahydrofuran
参考文献
Voskoboynikov, Alexander Z.; Ryabov, Alexey N.; Nikulin, Mikhail V.; Lygin, Alexander V.; Izmer, Vyatcheslav V.; Asachenko, Andrey F.; Coker, Catalina L.; Canich, Jo Ann M.
Patent: US2007/135593 A1, 2007 ;
反应条件
(IPr)Ni(π-allyl)Cl in tetrahydrofuran
T=20°C; Kumada Cross-Coupling; 5 h; Inert atmosphere;
参考文献
Iglesias, Maria Jose; Prieto, Auxiliadora; Nicasio, M. Carmen
Organic Letters, 2012 , vol. 14, # 17 p. 4318 - 4321
反应条件
C68H72Cl2N6NiP2 in toluene
T=90°C; 16 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Chemistry - A European Journal, 2011 , vol. 17, # 18 p. 4972 - 4975
反应条件
in tetrahydrofuran
byproducts: MgBrCl; A THF soln. of mesitylmagnesium bromide was added to a suspn. of CuCl in THF at -20°C, allowed to react overnight at ambient temp. understirring (N2 atm.);; dioxane was added, filtered, evapd., dissolved in benzene, filtered, evapd. in vac. at ambient temp.; elem. anal.;;
参考文献
Tsuda, Tetsuo; Watanabe, Katsuhiko; Miyata, Kazuyoshi; Yamamoto, Hirotsugu; Saegusa, Takeo
Inorganic Chemistry, 1981 , vol. 20, p. 2728 - 2730
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=23°C; Negishi coupling; 8 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
tri-tert-butyl phosphine; Ni(acac)2 in tetrahydrofuran
T=20°C; Arylation; 18 h;
参考文献
Boehm, Volker P. W.; Weskamp, Thomas; Gstoettmayr, Christian W. K.; Herrmann, Wolfgang A.
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 9 p. X1602-1604
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
