2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With PEPPSITM-IPr; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
diethyl ether
Erwaermen auf Siedetemperatur;
参考文献
Fuson et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1464
反应条件
1: not given
View Scheme
参考文献
Gmelin Handbook: B: B-Verb.9, 6.1, page 258 - 268
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=60°C; 2 h; Inert atmosphere;
参考文献
Reeves, Jonathan T.; Fandrick, Daniel R.; Tan, Zhulin; Song, Jinhua J.; Lee, Heewon; Yee, Nathan K.; Senanayake, Chris H.
Organic Letters, 2010 , vol. 12, # 19 p. 4388 - 4391
反应条件
PEPPSI™-IPr catalyst in tetrahydrofuran
T=20°C; Kumada-Tamao-Corriu reaction; 24 h;
参考文献
Organ, Michael G.; Abdel-Hadi, Mirvat; Avola, Stephanie; Hadei, Niloufar; Nasielski, Joanna; O'Brien, Christopher J.; Valente, Cory
Chemistry - A European Journal, 2007 , vol. 13, # 1 p. 150 - 157
反应条件
1,3-bis(2,6-di-(i-propyl)phenyl)-4,5-dihydroimidazolium tetrafluoroborate; Ni(acac) in tetrahydrofuran
T=20°C; Kumada-Corriu cross-coupling; 18 h;
参考文献
Boehm, Volker P. W.; Gstoettmayr, Christian W. K.; Weskamp, Thomas; Herrmann, Wolfgang A.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 18 p. 3387 - 3389
反应条件
(IPr)Ni(π-allyl)Cl in tetrahydrofuran
T=20°C; Kumada Cross-Coupling; 2 h; Inert atmosphere;
参考文献
Iglesias, Maria Jose; Prieto, Auxiliadora; Nicasio, M. Carmen
Organic Letters, 2012 , vol. 14, # 17 p. 4318 - 4321
反应条件
diethyl ether
Behandeln des Reaktionsprodukts mit wss.Ammoniak und Ammoniumchlorid;
参考文献
Risaliti
Ricerca Scientifica, 1956 , vol. 26, p. 2512,2515
反应条件
1: benzyl (2R,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxilate; 2,4,6-trimethylphenylmagnesium bromide in dichloromethane
T=-78°C;
2: With tetrafluoroboric acid in dichloromethane
0.0833333 h;
3: methylmagnesium bromide in dichloromethane
参考文献
Ruano, Jose L. Garcia; Alemparte, Carlos; Aranda, M. Teresa; Zarzuelo, Maria M.
Organic Letters, 2003 , vol. 5, # 1 p. 75 - 78
反应条件
1: benzyl (2S,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxylate; 2,4,6-trimethylphenylmagnesium bromide in dichloromethane
T=-78°C;
2: With tetrafluoroboric acid in dichloromethane
T=-20°C; 0.0833333 h;
3: methylmagnesium bromide in dichloromethane
T=-20°C;
参考文献
Ruano, Jose L. Garcia; Alemparte, Carlos; Aranda, M. Teresa; Zarzuelo, Maria M.
Organic Letters, 2003 , vol. 5, # 1 p. 75 - 78
