2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
in diethyl ether; toluene
T=0°C; 1 h; Inert atmosphere;
参考文献
Khiar, Noureddine; Salvador, Alvaro; Valdivia, Victoria; Chelouan, Ahmed; Alcudia, Ana; Alvarez, Eleuterio; Fernandez, Inmaculada
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6510 - 6521
反应条件
1: methylmagnesium bromide; benzyl (2R,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxilate in dichloromethane
T=-78°C;
2: With tetrafluoroboric acid in dichloromethane
T=-20°C; 0.0833333 h;
3: 2,4,6-trimethylphenylmagnesium bromide in dichloromethane
T=-20°C; Further stages. Title compound not separated from byproducts.;
参考文献
Ruano, Jose L. Garcia; Alemparte, Carlos; Aranda, M. Teresa; Zarzuelo, Maria M.
Organic Letters, 2003 , vol. 5, # 1 p. 75 - 78
反应条件
1: With copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; lithium chloride in tetrahydrofuran
T=-78°C; 1 h;
2: With trifluoroacetic acid in tetrahydrofuran
T=-78 - 20°C; Further stages.;
参考文献
Mueller, Amanda J.; Jennings, Michael P.
Organic Letters, 2007 , vol. 9, # 25 p. 5327 - 5329
反应条件
Ni(PCy3)2Cl2 in tetrahydrofuran
T=20°C; Kumada coupling; Title compound not separated from byproducts;
参考文献
Labonne, Aurelie; Kribber, Thomas; Hintermann, Lukas
Organic Letters, 2006 , vol. 8, # 25 p. 5853 - 5856
反应条件
Ni(PCy3)2Cl2 in tetrahydrofuran
T=0 - 20°C; 7 h; Inert atmosphere;
参考文献
Hintermann, Lukas; Dang, Tuan Thanh; Labonne, Aurelie.; Kribber, Thomas; Xiao, Li; Naumov, Pance
Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7167 - 7179
反应条件
in tetrahydrofuran
soln. of MesMgBr added to suspn. of anhyd. AgCl (-25°C), mixt. stirred (18 h); filtered, filtrate evapd., dried (high vac., 2 h), redissolved in toluene (40°C), filtered, concd., allowed to stand (room temp.), mother liqor concd.; elem. anal. (all operations in absence of light);
参考文献
Meyer, Edouard Marc; Gambarotta, Sandro; Floriani, Carlo; Chiesi-Villa, Angiola; Guastini, Carlo
Organometallics, 1989 , vol. 8, p. 1067 - 1079
反应条件
in tetrahydrofuran
T=-78 - 23°C;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; FURUYA, Takeru; TANG, Pingping
Patent: WO2010/59943 A2, 2010 ;
Location in patent: Page/Page column 32; 33 ;
反应条件
diethyl ether
Behandeln des Reaktionsprodukts in Aceton mit wss. H2SO4;
参考文献
Bharucha; Weedon
Journal of the Chemical Society, 1953 , p. 1571,1576
反应条件
PEPPSITM-IPr in tetrahydrofuran; 1,3-dimethyl-imidazolidin-2-one
T=60°C; Negishi cross-coupling; 24 h; Inert atmosphere;
参考文献
Nasielski, Joanna; Hadei, Nilofaur; Achonduh, George; Kantchev, Eric Assen B.; O'Brien, Christopher J.; Lough, Alan; Organ, Michael G.
Chemistry - A European Journal, 2010 , vol. 16, # 35 p. 10844 - 10853
反应条件
1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; Ni(acac)2 in tetrahydrofuran
T=20°C; Arylation; 18 h;
参考文献
Boehm, Volker P. W.; Weskamp, Thomas; Gstoettmayr, Christian W. K.; Herrmann, Wolfgang A.
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 9 p. X1602-1604
