2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With PEPPSITM-IPr; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
NiF2; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in toluene
T=0 - 120°C; 4.5 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Hashimoto, Sigma; Ishizuka, Kentaro; Nakamura, Masaharu
Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11949 - 11963
反应条件
bis(1,3-dimesityl-1H-imidazol-2(3H)-ylidene)nickel(I) bromide in diethyl ether; benzene
T=20°C; Kumada coupling reaction; 20 h; Inert atmosphere;
参考文献
Zhang, Kainan; Conda-Sheridan, Martin; R. Cooke, Shayna; Louie, Janis
Organometallics, 2011 , vol. 30, # 9 p. 2546 - 2552
反应条件
1: o-di-fluorobenzene With [Ni(6-Mes)(PPh3)Br] in tetrahydrofuran
Kumada Cross-Coupling; 0.166667 h; Schlenk techniqueGlovebox;
2: 2,4,6-trimethylphenylmagnesium bromide in tetrahydrofuran
T=24.84°C; Kumada Cross-Coupling; 24 h; Schlenk techniqueGlovebox; TemperatureTimeReagent/catalyst;
参考文献
Page, Michael J.; Lu, Wei Y.; Poulten, Rebecca C.; Carter, Emma; Algarra, Andres G.; Kariuki, Benson M.; MacGregor, Stuart A.; Mahon, Mary F.; Cavell, Kingsley J.; Murphy, Damien M.; Whittlesey, Michael K.
Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2158 - 2167
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C;
参考文献
Widdowson, David A.; Zhang, Ying-Zhi
Tetrahedron, 1986 , vol. 42, # 7 p. 2111 - 2116
反应条件
Ni(PCy3)2Cl2; tri-cyclo-hexyl-phosphine in various solvent(s)
T=80°C; 15 h;
参考文献
Dankwardt, John W.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 18 p. 2428 - 2432
反应条件
2: AlCl3 / 80 °C
View Scheme
参考文献
Fuson; Baumgartner
Journal of the American Chemical Society, 1948 , vol. 70, p. 3255
参考文献
Lapkin; Lapkina
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 108,112,114;engl.Ausg.S.21 119
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1602,1607;engl.Ausg.S.22 1643
参考文献
Lapkin; Lapkina
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1602,1610; engl. Ausg. S. 1643, 1650
