1: 42 percent / K2CO3 / acetone; H2O / 5 h / Heating 2: 61 percent / MeLi / tetrahydrofuran / 2 h / -78 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 4.2 g / Et₃N / tetrahydrofuran / 3 h / 20 &deg;C<br />2: 76 percent / aq. AcOH / 20 h / 80 &deg;C<br />3: 65 percent / zinc; TiCl₄ / tetrahydrofuran / 5 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 76 percent / aq. AcOH / 20 h / 80 &deg;C<br />2: 65 percent / zinc; TiCl₄ / tetrahydrofuran / 5 h / Heating<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3903207', constants.ctx, '0')">titanium tetrachloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8973685', constants.ctx, '0')">zinc</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />McMurry reaction;&nbsp;5&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;