1,2-苯并异噻唑-3-酮合成路线 （共 63 条）
反应条件
dihydrogen peroxide in 1-methyl-pyrrolidin-2-one; water T=20°C; 0.5 h;
参考文献
TITAN CHEMICALS LIMITED; BERG, Carsten; Singh, Sangita
Patent: US2013/109864 A1, 2013 ;
Location in patent: Paragraph 0027; 0028; 0029; 0030 ;
反应条件
1: With tetrabutylammomium bromide; ethyl mercaptan sodium salt in water; chlorobenzene 2 h; Inert atmosphereReflux; 2: With sulfuryl dichloride; water in chlorobenzene T=5 - 80°C; 1 h;
参考文献
Sumitomo Seika Chemicals Co., Ltd.; KANDA, Hisaaki; KONISHI, Hirotsugu; YAMAGUCHI, Hiroki
Patent: EP2687520 A1, 2014 ;
Location in patent: Page/Page column 0078; 0079; 0080 ;
反应条件
1: With chlorine in water; chlorobenzene T=45 - 70°C; 5 h; 2: With water; sodium hydroxide in chlorobenzene T=65 - 70°C; ConcentrationTime;
参考文献
Sumitomo Seika Chemicals Co., Ltd.; HIYAMA, Takehiro; YOKOE, Ichiro; TAKEUCHI, Takeshi; SUZUKI, Michio
Patent: EP2687519 A1, 2014 ;
Location in patent: Paragraph 0039; 0040; 0042; 0043 ;
反应条件
ammonia in 1,4-dioxane T=50°C; 6 h;
参考文献
Shimizu, Masao; Shimazaki, Teruaki; Yoshida, Tetsuya; Ando, Wataru; Konakahara, Takeo
Tetrahedron, 2012 , vol. 68, # 21 p. 3932 - 3936
反应条件
ammonia in dichloromethane T=-15 - 20°C; 2 h;
参考文献
Pietka-Ottlik, Magdalena; Potaczek, Piotr; Piasecki, Egbert; Mlochowski, Jacek
Molecules, 2010 , vol. 15, # 11 p. 8214 - 8228
参考文献
Kamigata, Nobumasa; Hashimoto, Satoshi; Kobayashi, Michio; Nakanishi, Hiroshi
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 11 p. 3131 - 3136
反应条件
1: With acetamide; sodium methylate in toluene T=80°C; 2 h; 2: With dihydrogen peroxide T=50 - 55°C; 3: With hydrogenchloride T=25°C;
参考文献
Jin, Chun Keun; Moon, Jung-Kyen; Lee, Woo Song; Nam, Keun Soo
Synlett, 2003 , # 13 p. 1967 - 1968
反应条件
potassium hydroxide in ethanol T=20°C; Cyclization; 0.5 h;
参考文献
Shimizu, Masao; Kikumoto, Hisashi; Konakahara, Takeo; Gama, Yasuo; Shibuya, Isao
Heterocycles, 1999 , vol. 51, # 12 p. 3005 - 3012
反应条件
sulfuryl dichloride in toluene
参考文献
Sumitomo Seika Chemicals Co., Ltd.; Sumitomo Chemical Co., Ltd.
Patent: US5508416 A1, 1996 ;
反应条件
potassium hydroxide in ethanol T=20°C; Cyclization; 0.5 h;
参考文献
Shimizu, Masao; Kikumoto, Hisashi; Konakahara, Takeo; Gama, Yasuo; Shibuya, Isao
Heterocycles, 1999 , vol. 51, # 12 p. 3005 - 3012
