1,2-苯并异噻唑-3-酮合成路线 （共 63 条）
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C 2: ammonia / 1,4-dioxane / 6 h / 50 °C View Scheme
参考文献
Shimizu, Masao; Shimazaki, Teruaki; Yoshida, Tetsuya; Ando, Wataru; Konakahara, Takeo
Tetrahedron, 2012 , vol. 68, # 21 p. 3932 - 3936
反应条件
1: sodium sulfide hydrate / 1-methyl-pyrrolidin-2-one / 4 h / 160 °C 2: dihydrogen peroxide / 1-methyl-pyrrolidin-2-one; water / 0.5 h / 20 °C View Scheme
参考文献
TITAN CHEMICALS LIMITED; BERG, Carsten; Singh, Sangita
Patent: US2013/109864 A1, 2013 ;
反应条件
sodium methylate Cyclization; alkoxylation; 3 h; Heating;
参考文献
Shimizu, Masao; Kikumoto, Hisashi; Konakahara, Takeo; Gama, Yasuo; Shibuya, Isao
Heterocycles, 1999 , vol. 51, # 12 p. 3005 - 3012
参考文献
McKibben; McClelland
Journal of the Chemical Society, 1923 , vol. 123, p. 171,172
反应条件
potassium carbonate in acetonitrile 24 h; Reflux;
参考文献
Matuszak, Nicolas; Es Saadi, Bouazza; Labar, Geoffray; Marchand-Brynaert, Jacqueline; Lambert, Didier M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7321 - 7324
反应条件
tert-butylhypochlorite in 1,2-dichloro-ethane
参考文献
Levchenko,E.S.; Dubinina,T.N.
Zhurnal Organicheskoi Khimii, 1978 , vol. 14, p. 862 - 866,798 - 802
反应条件
1: POCl3 / pyridine / 120 - 140 °C 2: Na View Scheme
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1968 , vol. 23, p. 1081 - 1096
反应条件
NaSH in aq. buffer T=20°C; pH=3; MechanismKinetics; Reagent/catalyst;
参考文献
Frerot, Eric; Bagnoud, Alain; Cicchetti, Esmeralda
ChemPlusChem, 2014 , vol. 79, # 1 p. 77 - 82
反应条件
1: 77 percent / POCl3 / 3.5 h / 20 - 120 °C 2: 68 percent / 24 h / 125 °C View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
in chlorobenzene; paraffin oil
参考文献
Bayer Aktiengesellschaft
Patent: US5883258 A1, 1999 ;
