4-溴-1,2-亚甲二氧基苯合成路线 （共 128 条）
反应条件
KF in 1,2-dioxacyclohexane
参考文献
Yale University
Patent: US6562989 B2, 2003 ;
反应条件
sodium carbonate; tris[(perfluoroalkyl)phenyl]phosphane palladium in methanol T=75°C; Suzuki coupling; 2 h;
参考文献
Schneider, Siegfried; Bannwarth, Willi
Helvetica Chimica Acta, 2001 , vol. 84, # 3 p. 735 - 742
反应条件
cBRIDP; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate in water T=50°C; 24 h; Inert atmosphereGreen chemistry;
参考文献
Isley, Nicholas A.; Dobarco, Sebastian; Lipshutz, Bruce H.
Green Chemistry, 2014 , vol. 16, # 3 p. 1480 - 1488
反应条件
phosphorus pentachloride
参考文献
Merck Patent Gesellschaft mit beschrankter Haftung
Patent: US5635107 A1, 1997 ;
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 2 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With ammonia; iodine in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Tetrahedron, , vol. 69, # 5 p. 1462 - 1469
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in water; tert-butyl alcohol T=85°C; 12 h; Inert atmosphere;
参考文献
Chemical Communications, , vol. 48, # 23 p. 2909 - 2911
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With magnesium; lithium chloride in tetrahydrofuran T=20°C; Inert atmosphere; 2: N-cyano-N-phenyl-p-methylbenzenesulfonamide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 17, # 15 p. 4217 - 4222
反应条件
in N,N-dimethyl-formamide T=130°C;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 18 p. 5823 - 5836
参考文献
Journal of Organic Chemistry, , vol. 23, p. 908
反应条件
sodium carbonate; [(t-Bu)3PH]BF4; palladium diacetate in 1-methyl-pyrrolidin-2-one; water T=130°C; 24 h;
参考文献
Scrivanti, Alberto; Bertoldini, Matteo; Beghetto, Valentina; Matteoli, Ugo
Tetrahedron, 2008 , vol. 64, # 3 p. 543 - 548
