1,3-二(4-甲氧基苯基)-2-丙基-1,3-丙二酮合成路线 （共 10 条）
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
Stauffer; Coletta; Tedesco; Nishiguchi; Carlson; Sun; Katzenellenbogen
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4934 - 4947
反应条件
pyridinium chlorochromate in dichloromethane
T=0 - 20°C; 4 h; Inert atmosphereMolecular sieve;
参考文献
Sanchez-Carmona, Miguel A.; Contreras-Cruz, David A.; Miranda, Luis D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6506 - 6508
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 0 - 20 °C
2: 76 percent / LHMDS / tetrahydrofuran / 1.5 h / 20 °C
View Scheme
参考文献
Stauffer; Coletta; Tedesco; Nishiguchi; Carlson; Sun; Katzenellenbogen
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4934 - 4947
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 0 - 20 °C
2: 76 percent / LHMDS / tetrahydrofuran / 1.5 h / 20 °C
View Scheme
参考文献
Stauffer; Coletta; Tedesco; Nishiguchi; Carlson; Sun; Katzenellenbogen
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4934 - 4947
反应条件
1: diisopropylcarbodiimide; 4-(dimethylamino)pyridine / tetrahydrofuran
2: 76 percent / LHMDS / tetrahydrofuran / 1.5 h / 20 °C
View Scheme
参考文献
Stauffer; Coletta; Tedesco; Nishiguchi; Carlson; Sun; Katzenellenbogen
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4934 - 4947
反应条件
1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
View Scheme
参考文献
Sanchez-Carmona, Miguel A.; Contreras-Cruz, David A.; Miranda, Luis D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6506 - 6508
反应条件
1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
View Scheme
参考文献
Sanchez-Carmona, Miguel A.; Contreras-Cruz, David A.; Miranda, Luis D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6506 - 6508
反应条件
1: sodium hydride / dimethyl sulfoxide / 8 °C
2: potassium tert-butylate / tetrahydrofuran / Reflux
View Scheme
参考文献
Schaefer, Anja; Wellner, Anja; Gust, Ronald
ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803
反应条件
1: sodium hydride / dimethyl sulfoxide / 8 °C
2: potassium tert-butylate / tetrahydrofuran / Reflux
View Scheme
参考文献
Schaefer, Anja; Wellner, Anja; Gust, Ronald
ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803
反应条件
potassium tert-butylate in tetrahydrofuran
Reflux;
参考文献
Schaefer, Anja; Wellner, Anja; Gust, Ronald
ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803
