5-氰基异吲哚啉-2-羧酸叔丁酯合成路线 （共 6 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 4 h;
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
pyridine; p-toluenesulfonyl chloride T=20°C; Neat (no solvent);
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/37788 A1, 2004 ;
Location in patent: Page 15 ;
WO 2004/037788 A1
反应条件
1: 40 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2: 70 percent / Et3N / CH2Cl2 / 6 h / -20 - 20 °C 3: 90 percent / Pd(PPh3)4 / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
1: 80 percent / aq. HBr / 2 h / 100 °C 2: 40 percent / Et3N / CH2Cl2 / 16 h / 20 °C 3: 70 percent / Et3N / CH2Cl2 / 6 h / -20 - 20 °C 4: 90 percent / Pd(PPh3)4 / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
1: 40 percent / Et3N / CH2Cl2 / 16 h / 20 °C 2: 70 percent / Et3N / CH2Cl2 / 6 h / -20 - 20 °C 3: 90 percent / Pd(PPh3)4 / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
1: 70 percent / Et3N / CH2Cl2 / 6 h / -20 - 20 °C 2: 90 percent / Pd(PPh3)4 / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
