N-(环丙基甲基)环丙烷甲酰胺合成路线 （共 3 条）
反应条件
1: cyclopropanecarboxylic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0°C; 0.5 h; 2: With benzotriazol-1-ol; triethylamine in dichloromethane T=0°C; 0.666667 h; 3: (cyclopropylmethyl)amine in dichloromethane T=20°C;
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 211-212 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 20 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1935883 A1, 2008 ;
Location in patent: Page/Page column 37 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
George, Tesmol G.; Johnsamuel, Jayaseharan; Delfin, Dawn A.; Yakovich, Adam; Mukherjee, Mitali; Phelps, Mitch A.; Dalton, James T.; Sackett, Dan L.; Kaiser, Marcel; Brun, Reto; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5699 - 5710
