2-氰基-N,N-二乙基乙酰胺合成路线 （共 13 条）
反应条件
1: diethylamine With n-hexyl lithium in tetrahydrofuran; hexanes T=-30°C; 1.5 h; 2: cyanoacetic acid ethyl ester in tetrahydrofuran; hexanes T=-30 - 20°C; 0.5 h;
参考文献
Hansen, Klaus; Kraemer, Robert; Lauterbach, Thomas; Schmidt, Dirk; Paar, Fritz; Pfeiffer, Petra; Geffken, Detlef; Thimann, Wolfgang; Wehner, Katharina
Patent: US2008/103191 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
dicyclohexyl-carbodiimide in ethyl acetate T=25 - 40°C;
参考文献
CILAG AG
Patent: WO2005/63695 A1, 2005 ;
Location in patent: Page/Page column 10; 11 ;
参考文献
Sasaki,T.; Kojima,A.
Journal of the Chemical Society [Section] C: Organic, 1970 , p. 476 - 480
反应条件
acetic acid; glycine in toluene Knoevenagel Condensation; 12 - 15 h; Heating / reflux;
参考文献
SUVEN LIFE SCIENCES LTD.,
Patent: WO2007/94007 A1, 2007 ;
Location in patent: Page/Page column 14-15 ;
反应条件
sodium hydroxide in methanol T=20°C; 16 h;
参考文献
Dipharma Francis S.r.l.
Patent: EP1935873 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
piperidine; acetic acid in toluene T=105 - 110°C; 15 h; Heating / reflux;
参考文献
SUVEN LIFE SCIENCES LTD; JASTI, Venkat
Patent: WO2005/63693 A1, 2005 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHOU, Dongsheng; LIU, Liu; MAO, Bin; LIU, Yun
Patent: WO2013/149566 A1, 2013 ;
反应条件
1: With piperidine in ethylene glycol dimethyl ether; n-heptane 15 - 25 h; Heating / reflux; 2: in dichloromethane T=25 - 35°C; 24 h; Product distribution / selectivity;
参考文献
SANMAR SPECIALITY CHEMICALS LTD; CHITTOOR, Ghatambu, Sethuram; UDAY, Rajaram, Bapat; MUNUSAMY, Jayamani; MUPPID, Naga, Venkata, Satya, Prasanna, Anjaneya, Radha, Krishna, Murthy
Patent: WO2007/77572 A1, 2007 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: With piperidine in isopropyl alcohol 12 - 15 h; Heating / reflux; 2: With acetic acid in isopropyl alcohol T=20°C;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; KHAN, Rashid, Abdul, Rehman; YADAV, Ram, Prasad; SHAIKH, Zakir, Gafoor
Patent: WO2005/66117 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid 3: AlCl3, aluminium chloride / N,N-dimethyl-formamide / 100 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHOU, Dongsheng; LIU, Liu; MAO, Bin; LIU, Yun
Patent: WO2013/149566 A1, 2013 ;
