反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.166667 h;
2: 1-(3,4-dichlorophenyl)-ethanone in tetrahydrofuran; hexane
T=20°C; 18 h; Further stages.;
参考文献
Edwards, Philip D.; Albert, Jeffrey S.; Sylvester, Mark; Aharony, David; Andisik, Donald; Callaghan, Owen; Campbell, James B.; Carr, Robin A.; Chessari, Gianni; Congreve, Miles; Frederickson, Martyn; Folmer, Rutger H. A.; Geschwindner, Stefan; Koether, Gerard; Kolmodin, Karin; Krumrine, Jennifer; Mauger, Russell C.; Murray, Christopher W.; Olsson, Lise-Lotte; Patel, Sahil; Spear, Nate; Tian, Gaochao
Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 5912 - 5925