4-氯-6-甲氧基-7-[3-(4-甲基哌嗪-1-基)丙氧基]喹唑啉合成路线 （共 4 条）
反应条件
di-tert-butylazodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 12 h;
参考文献
Tasler, Stefan; Mueller, Oliver; Wieber, Tanja; Herz, Thomas; Pegoraro, Stefano; Saeb, Wael; Lang, Martin; Krauss, Rolf; Totzke, Frank; Zirrgiebel, Ute; Ehlert, Jan E.; Kubbutat, Michael H.G.; Schaechtele, Christoph
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6728 - 6737
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide)
0.5 h; Heating / reflux;
参考文献
AstraZeneca AB
Patent: EP1119567 B1, 2005 ;
Location in patent: Page/Page column 34 ;
反应条件
thionyl chloride in methanol; dichloromethane; water; N,N-dimethyl-formamide
参考文献
Lambert, Christine Marie Paul; Ple, Patrick
Patent: US2004/44015 A1, 2004 ;
反应条件
thionyl chloride in methanol; dichloromethane; water; N,N-dimethyl-formamide
参考文献
AstraZeneca AB
Patent: US2004/48881 A1, 2004 ;
US 20040048881 A1
