2,3-二氢-1H-茚-1-羧酸甲酯合成路线 （共 20 条）
参考文献
Adir et Compagnie
Patent: US5194437 A1, 1993 ;
反应条件
in dichloromethane
3 h;
参考文献
Katz, Christopher E.; Aube, Jeffrey
Journal of the American Chemical Society, 2003 , vol. 125, # 46 p. 13948 - 13949
反应条件
1: 56 percent / diethylamine, tosyl azide (TsN3) / diethyl ether / 4 h / Ambient temperature
2: 44 percent / 5 h / Irradiation
View Scheme
参考文献
Tamura, Yasumitsu; Ikeda, Hiroyuki; Mukai, Chisato; Bayomi, Said Mohamad M.; Ikeda, Masazumi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3430 - 3433
反应条件
n-butyllithium; zinc dibromide
1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 4 h; -78 deg C to room temperature, overnight, 3.) CHCl2CHCl2, 140 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Xie, Linghong; Serdyuk, Larisa
Journal of Organic Chemistry, 1996 , vol. 61, # 21 p. 7564 - 7570
反应条件
1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine in n-heptane
T=40°C; 2 h; Kinetics;
参考文献
Pietruszka, Joerg; Simon, Robert Christian; Kruska, Fabian; Braun, Manfred
European Journal of Organic Chemistry, 2009 , # 35 p. 6217 - 6224
反应条件
1: (i), (ii) Ac2O, (iii) KOtBu, tBuOH
2: HCl
View Scheme
参考文献
Ogura,K. et al.
Synthesis, 1979 , p. 880 - 882
参考文献
Ogura,K. et al.
Synthesis, 1979 , p. 880 - 882
反应条件
1: Raney nickel; aqueous NaOH / Hydrogenation
2: H2SO4
View Scheme
参考文献
Wunderlich
Archiv der Pharmazie (Weinheim, Germany), 1953 , vol. 286, p. 512,515
反应条件
1: sodium; N-methyl-aniline; naphthalene / weiteres Reagens: Aether
2: Raney nickel; aqueous NaOH / Hydrogenation
3: H2SO4
View Scheme
参考文献
Wunderlich
Archiv der Pharmazie (Weinheim, Germany), 1953 , vol. 286, p. 512,515
参考文献
Tamura, Yasumitsu; Ikeda, Hiroyuki; Mukai, Chisato; Bayomi, Said Mohamad M.; Ikeda, Masazumi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3430 - 3433
